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Deanna MacNeil, PhD | Dec 16, 2022 | 4 min read

Researchers employ peripheral blood mononuclear cells (PBMCs) in clinical and academic applications related to the immune system and regenerative medicine.

Peripheral blood mononuclear cells surrounded by red blood cells in circulating blood.

Accelerating Immune Research with Cryopreserved Peripheral Blood Mononuclear Cells

The Scientist’s Creative Services Team and MilliporeSigma | Jul 18, 2022 | 3 min read

Commerically-available peripheral blood mononuclear cells offer a well-characterized, accessible, and consistent model for immunology and therapeutic development.

Doubts Raised Over Whether Mice Can Truly Inherit Immunity

David Adam | Jan 26, 2022 | 3 min read

An independent lab fails to replicate results suggesting mammals exposed to pathogens could pass on immunological protections through epigenetic mechanisms.

white adult mouse with 4 pups on white background

Mice that Survive Infection Pass on Stronger Immunity

David Adam | Oct 18, 2021 | 3 min read

Offspring of animals subjected to a real or simulated pathogen were more able to fend off disease, a study finds.

Infographic: How Vaccines Train Innate Immunity

Shawna Williams | Nov 1, 2020 | 1 min read

A recent study elucidates some of the changes that occur in the body after inoculation with a tuberculosis vaccine.

covid-19 sars-cov-2 coronavirus pandemic immune response severity severe biomarkers prognostic predictor neutrophil monocyte myeloid cytokine interleukin

The Immune Hallmarks of Severe COVID-19

Katarina Zimmer | Sep 16, 2020 | 10+ min read

Researchers are trying to make sense of immune systems gone haywire and develop biomarkers to predict who will become the sickest from a coronavirus infection.

stroke, animal model, mouse model, blood, cytokine storm, immune system, immune response, MMP-9, neutrophil

Blood Replacement Rescues Mice from Stroke Damage

Amanda Heidt | Aug 31, 2020 | 5 min read

When mice that had suffered a stroke were given blood from a healthy donor, they experienced less tissue and neurological damage.

bcg tuberculosis tb sars-cov-2 covid-19 coronavirus pandemic vaccine nonspecific effects trained immunity innate immune system response

An Old TB Vaccine Finds New Life in Coronavirus Trials

Anthony King | May 4, 2020 | 8 min read

Studies are underway to test whether giving a shot of BCG vaccine could protect doctors and nurses against COVID-19.

blood vessel hydrogel microvasculature endothelium

Image of the Day: New Growth

Chia-Yi Hou | Apr 12, 2019 | 1 min read

Injection of a hydrogel that mechanically resembles a blood clot promotes the growth of new blood vessels in mice.

Exosomes Linked to Cancer Spread from Chemoresistant Tumors in Mice

Carolyn Wilke | Jan 10, 2019 | 4 min read

The vesicles promote metastasis after chemotherapy, but the authors say the results shouldn’t alarm patients and may point to ways to improve treatments.

Image of the Day: Brain, Heal Thyself

The Scientist Staff and The Scientist Staff | Apr 20, 2018 | 1 min read

When a mouse’s brain undergoes traumatic injury, immune cells clear the dead from the affected area, after which blood cells swoop in to repair blood vessels.