The Immune Hallmarks of Severe COVID-19

Researchers are trying to make sense of immune systems gone haywire and develop biomarkers to predict who will become the sickest from a coronavirus infection.

Written byKatarina Zimmer
| 12 min read
covid-19 sars-cov-2 coronavirus pandemic immune response severity severe biomarkers prognostic predictor neutrophil monocyte myeloid cytokine interleukin

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ABOVE: Scanning electron microscope image of SARS-CoV-2 (gold) emerging from the surface of cells cultured in the lab. The virus shown was isolated from a patient in the US. Image captured and colorized at NIAID’s Rocky Mountain Laboratories (RML) in Hamilton, Montana
FLICKR, NIAID

One of the most striking features of SARS-CoV-2, the virus that causes COVID-19, is the exceptional breadth of symptoms it causes in people. Of the nearly 30 million recorded infections to date, the vast majority of people experienced mild or moderate disease—which itself can range from no symptoms at all to pneumonia or long-term, debilitating neurological symptoms. A minority ended up with severe respiratory symptoms but eventually recovered. And some—nearly 940,000 worldwide, of which 196,000 are in the US—took a turn for the worse and died.

Why some people die while others recover is thought to depend in large part on the human immune response, which spirals ...

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Meet the Author

  • katya katarina zimmer

    After a year teaching an algorithm to differentiate between the echolocation calls of different bat species, Katarina decided she was simply too greedy to focus on one field of science and wanted to write about all of them. Following an internship with The Scientist in 2017, she’s been happily freelancing for a number of publications, covering everything from climate change to oncology. Katarina is a news correspondent for The Scientist and contributes occasional features to the magazine. Find her on Twitter @katarinazimmer and read her work on her website.

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