Patients with the rare autoimmune condition, highlighted in the Oscar-nominated film The Big Sick, currently have limited treatment options.

At low doses, resveratrol enhanced human T-cell activity in vitro, while at high doses it interfered with cell signaling. 

Instructor, Department of Systems Biology, University of Texas MD Anderson Cancer Center. Age: 38

In mice, cancer cells genetically modified to express an anticancer cytokine home to tumors and can reduce their growth. 

Engineered cells detect early biomarkers of a psoriasis flare-up in mice and release compounds to soothe or prevent the skin reaction.

In mice lacking intestinal microbiota, white fat turns brown and obesity is prevented.

Researchers characterize a protein that could be key to the virus’s virulence—and to developing a vaccine against the mosquito-borne disease.

An innate immune pathway stimulates the activity of heat-producing adipose tissue in mice.

Commercial kits use fluorescent beads to probe dozens of cytokines in one reaction.

Sorting out T-cell functional and phenotypic heterogeneity depends on studying single cells.