Spleen-to-Liver Signals Control Systemic Inflammation
Spleen-to-Liver Signals Control Systemic Inflammation
In rats, the spleen directs a cytokine surge that drives system-wide inflammation, but it is not, as once believed, the main producer of the chemical messenger.
Spleen-to-Liver Signals Control Systemic Inflammation
Spleen-to-Liver Signals Control Systemic Inflammation

In rats, the spleen directs a cytokine surge that drives system-wide inflammation, but it is not, as once believed, the main producer of the chemical messenger.

In rats, the spleen directs a cytokine surge that drives system-wide inflammation, but it is not, as once believed, the main producer of the chemical messenger.

cytokines
Immune Cell Activity Mediates Severe COVID-19 Pathogenesis
Immune Cell Activity Mediates Severe COVID-19 Pathogenesis
The Scientist Creative Services Team in Collaboration with IsoPlexis | Jun 15, 2021
Functional profiling of immune cells uncovers targetable mechanisms underlying lung inflammation in severe COVID disease.
Advancing Cancer Biomarker Detection with Single Cell Proteomics
Advancing Cancer Biomarker Detection with Single Cell Proteomics
The Scientist Creative Services Team in Collaboration with IsoPlexis | May 31, 2021
An improved ELISA-based proteomics chip detects cytokines in single cell applications.
Boosting CAR T Cell Therapy for Solid Tumors
Boosting CAR T Cell Therapy for Solid Tumors
The Scientist Creative Services Team in Collaboration with IsoPlexis | Apr 5, 2021
Katie McKenna will discuss how oncolytic viral therapy enhances CAR-T cell killing of cancer cells.
Cancer Vaccines: Raising a T Cell Army
Cancer Vaccines: Raising a T Cell Army
The Scientist Creative Services Team | Apr 1, 2021
Vaccines against various forms of cancer prime the immune system to attack.
Understanding Transplant Rejection with Single-Cell Proteomics
Understanding Transplant Rejection with Single-Cell Proteomics
The Scientist Creative Services Team | Mar 9, 2021
Researchers find key drivers of allograft rejection!
Performing Metabolomic and Functional Proteomic Analyses on a Heterogenous Cancer Cell Population
Performing Metabolomic and Functional Proteomic Analyses on a Heterogenous Cancer Cell Population
The Scientist Creative Services Team in Collaboration with IsoPlexis | Mar 1, 2021
A tumor metabolome panel identifies altered cell states that lead to drug tolerance.
Identifying PrognosticBiomarkers in COVID-19<br>
Identifying PrognosticBiomarkers in COVID-19
The Scientist Creative Services Team | Dec 21, 2020
Single-cell proteomics provides novel insights to COVID-19 disease progression
Key Genes Related to Severe COVID-19 Infection Identified
Key Genes Related to Severe COVID-19 Infection Identified
Max Kozlov | Dec 14, 2020
Differences in the expression of genes associated with antiviral immunity and lung inflammation may contribute to a more serious COVID-19 infection.
Infographic: How Vaccines Train Innate Immunity
Infographic: How Vaccines Train Innate Immunity
Shawna Williams | Nov 1, 2020
A recent study elucidates some of the changes that occur in the body after inoculation with a tuberculosis vaccine.
Decoy Cells Trick SARS-CoV-2, Reduce Cytokines In Vitro
Decoy Cells Trick SARS-CoV-2, Reduce Cytokines In Vitro
Max Kozlov | Oct 14, 2020
Genetically engineered cells that overproduce ACE2, the receptor the novel coronavirus uses to enter cells, neutralize infection in vitro and mop up inflammatory cytokines in mice.
T Cells and Neurons Talk to Each Other
T Cells and Neurons Talk to Each Other
Ashley Yeager | Oct 1, 2020
Conversations between the immune and central nervous systems are proving to be essential for the healthy social behavior, learning, and memory.
The Brain&rsquo;s Immune Cells Stand Sentinel Against Viral Invasion
The Brain’s Immune Cells Stand Sentinel Against Viral Invasion
Ashley Yeager | Oct 1, 2020
Some viruses, possibly even SARS-CoV-2, can sneak into the brain through the nose. Recent studies show that microglia are ready for them when they do.
Infographic: How Cytokines Flow into and out of the Brain
Infographic: How Cytokines Flow into and out of the Brain
Ashley Yeager | Oct 1, 2020
Several routes exist for immune cells to communicate with neurons in the central nervous system, though T cells rarely come in direct contact with neural tissue.
p53 as an Immune System Modulator in Cancer
p53 as an Immune System Modulator in Cancer
The Scientist Creative Services Team | Sep 25, 2020
Best known as a cell cycle regulator, p53 signaling mediates pro and anti-cancer immune responses as well
Special Report
The Immune Hallmarks of Severe COVID-19
The Immune Hallmarks of Severe COVID-19
Katarina Zimmer | Sep 16, 2020
Researchers are trying to make sense of immune systems gone haywire and develop biomarkers to predict who will become the sickest from a coronavirus infection.
Immune Cell and Its Cytokine Control Exploratory Behavior in Mice
Immune Cell and Its Cytokine Control Exploratory Behavior in Mice
Ashley Yeager | Sep 14, 2020
Gamma delta T cells in the meninges of the brain release a cell signaling molecule that does more than protect mice from microbial pathogens.
Blood Replacement Rescues Mice from Stroke Damage
Blood Replacement Rescues Mice from Stroke Damage
Amanda Heidt | Aug 31, 2020
When mice that had suffered a stroke were given blood from a healthy donor, they experienced less tissue and neurological damage.
Is a Bradykinin Storm Brewing in COVID-19?
Is a Bradykinin Storm Brewing in COVID-19?
Alakananda Dasgupta | Aug 26, 2020
Excess of the inflammatory molecule bradykinin may explain the fluid build-up in the lungs of patients with coronavirus infections. Clinical trials of inhibitors are putting this hypothesis to the test.
Infographic: SARS-CoV-2 Interferes with Bradykinin Regulation
Infographic: SARS-CoV-2 Interferes with Bradykinin Regulation
Alakananda Dasgupta | Aug 26, 2020
The leaky blood vessels and lung fluid build-up in some COVID-19 patients might be explained by the virus’s corruption of an inflammation safeguard.