mouse model

New research in mice reveals why natural killer cells, normally effective at hunting cancer, are sometimes stopped in their tracks.  

Researchers find a way to wipe out the brain’s immune cell corps and send in new and improved versions.

Roseolovirus infection disrupts how the body trains immune cells not to attack it, a mouse study shows.

Signals from sweeteners and sugars are relayed from the gut to the brain by different neural pathways, a new study concludes.

Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.

Researchers link a missense mutation in the B4GALT1 gene to lower levels of LDL cholesterol and the blood clotting factor fibrinogen.

Tracking human cancers in mice shows some unexpected cell changes that could undermine translational research.  

Researchers link the ability of the cells to bind and present DNA from pathogens and cell death to anemia, which is common in COVID-19, and immune activation.

Ancient and modern genomes reveal that a variant of the human growth hormone receptor likely helped our ancestors survive when food was scarce.

A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.

Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.

Researchers show that both mice and pigs are capable of oxygenating their blood via the colon—a capacity that, if shared by humans, could be leveraged in the clinic to minimize the need for mechanical ventilation.

Researchers insert functioning cone photoreceptors into the retinas of mice with advanced eye disease, improving their vision.

Manipulating the activity of neurons active during training had similar effects on the mice’s behavior.

Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.

A study finds that β-coronaviruses don’t use the normal secretory pathway, a possible explanation for some aspects of COVID-19 pathology.