Tracking human cancers in mice shows some unexpected cell changes that could undermine translational research.  

Researchers link the ability of the cells to bind and present DNA from pathogens and cell death to anemia, which is common in COVID-19, and immune activation.

Ancient and modern genomes reveal that a variant of the human growth hormone receptor likely helped our ancestors survive when food was scarce.

A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.

Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.

Researchers show that both mice and pigs are capable of oxygenating their blood via the colon—a capacity that, if shared by humans, could be leveraged in the clinic to minimize the need for mechanical ventilation.

Researchers insert functioning cone photoreceptors into the retinas of mice with advanced eye disease, improving their vision.

Manipulating the activity of neurons active during training had similar effects on the mice’s behavior.

Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.

A study finds that β-coronaviruses don’t use the normal secretory pathway, a possible explanation for some aspects of COVID-19 pathology.

Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.

When mice that had suffered a stroke were given blood from a healthy donor, they experienced less tissue and neurological damage.

Two studies show that Plasmodium—the genus of protozoans that cause malaria—have an internal sense of time that synchronizes with their host’s circadian rhythms and allows the parasites to collectively attack blood cells.

Two rodent models of glaucoma have defects in the waste drainage system.

Nimodipine, a drug used to treat brain hemorrhages, alleviates spasticity in mice after spinal cord injuries.

Researchers slowed disease progression in the mice by injecting two different viral vectors, each containing one part of the DNA encoding the Cas9 protein, to edit the causative gene.

A fluorescent image of murine hippocampal cells is the winning microscopy image from more than 400 submissions from 65 countries for Olympus’s 2019 Image of the Year Award.