An illustration shows circular red blood cells running into a yellow cholesterol blockage in a transverse section of an artery on a blue and purple background
Genetic Variant Discovered in Amish Protects from Heart Disease
Researchers link a missense mutation in the B4GALT1 gene to lower levels of LDL cholesterol and the blood clotting factor fibrinogen.
ABOVE: © ISTOCK.COM, RASI BHADRAMANI
Genetic Variant Discovered in Amish Protects from Heart Disease
Genetic Variant Discovered in Amish Protects from Heart Disease

Researchers link a missense mutation in the B4GALT1 gene to lower levels of LDL cholesterol and the blood clotting factor fibrinogen.

Researchers link a missense mutation in the B4GALT1 gene to lower levels of LDL cholesterol and the blood clotting factor fibrinogen.

ABOVE: © ISTOCK.COM, RASI BHADRAMANI
mouse model
grey and purple cancer cells under a microscope
Cell Diversity Could Spell Trouble for Animal Models of Cancer
David Adam | Nov 19, 2021
Tracking human cancers in mice shows some unexpected cell changes that could undermine translational research.  
Red blood cells are pictured in grayscale on a gray background
Red Blood Cells Activate Innate Immune System
Abby Olena | Oct 20, 2021
Researchers link the ability of the cells to bind and present DNA from pathogens and cell death to anemia, which is common in COVID-19, and immune activation.
group of paleolithic people around a campfire
Gene Variant Points to Starvation’s Evolutionary Legacy
Sophie Fessl | Sep 28, 2021
Ancient and modern genomes reveal that a variant of the human growth hormone receptor likely helped our ancestors survive when food was scarce.
ribbon model of phenylalanine hydroxylase enzyme
Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder
Abby Olena | Aug 6, 2021
A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.
A black mouse runs on a yellow and green spinning wheel against a blue background
Exercising During Pregnancy Protects Mouse Offspring
Jack J. Lee | Aug 1, 2021
Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.
An illustrated schematic with a blue background describes how oxygenated perfluorocarbon can rescue respiratory failure in mammals.
Mammals Can Use Their Intestines to Breathe
Abby Olena | May 14, 2021
Researchers show that both mice and pigs are capable of oxygenating their blood via the colon—a capacity that, if shared by humans, could be leveraged in the clinic to minimize the need for mechanical ventilation.
illustration of different cells types in retina
Cones Derived from Human Stem Cells Help Mice See: Study
Marcus A. Banks | Apr 23, 2021
Researchers insert functioning cone photoreceptors into the retinas of mice with advanced eye disease, improving their vision.
Early Training Forestalls Motor, Memory Difficulties in Mouse Model of Rett Syndrome
Laura Dattaro | Mar 29, 2021
Manipulating the activity of neurons active during training had similar effects on the mice’s behavior.
A Tweak to Immune Cells Reverses Aging in Mice
Abby Olena | Jan 20, 2021
Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.
SARS-CoV-2 Exits Cells Via Lysosomes
Abby Olena | Nov 13, 2020
A study finds that β-coronaviruses don’t use the normal secretory pathway, a possible explanation for some aspects of COVID-19 pathology.
Study Points to Novel Role for Microglia in Down Syndrome
Catherine Offord | Oct 6, 2020
Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.
stroke, animal model, mouse model, blood, cytokine storm, immune system, immune response, MMP-9, neutrophil
Blood Replacement Rescues Mice from Stroke Damage
Amanda Heidt | Aug 31, 2020
When mice that had suffered a stroke were given blood from a healthy donor, they experienced less tissue and neurological damage.
Malaria Parasites’ Biological Clocks Coordinate Cell Destruction
Abby Olena | May 14, 2020
Two studies show that Plasmodium—the genus of protozoans that cause malaria—have an internal sense of time that synchronizes with their host’s circadian rhythms and allows the parasites to collectively attack blood cells.
Quasi-Lymphatic System in the Rodent Eye Clears Waste
Abby Olena | Apr 16, 2020
Two rodent models of glaucoma have defects in the waste drainage system.
Image of the Day: Muting Muscle Spasms
Amy Schleunes | Apr 16, 2020
Nimodipine, a drug used to treat brain hemorrhages, alleviates spasticity in mice after spinal cord injuries.
Symptoms in ALS Mouse Model Improve with CRISPR Base Editing
Abby Olena | Apr 10, 2020
Researchers slowed disease progression in the mice by injecting two different viral vectors, each containing one part of the DNA encoding the Cas9 protein, to edit the causative gene.
Image of the Day: A Mouse Brain Slice Becomes Art
Amy Schleunes | Apr 1, 2020
A fluorescent image of murine hippocampal cells is the winning microscopy image from more than 400 submissions from 65 countries for Olympus’s 2019 Image of the Year Award.