Study Points to Novel Role for Microglia in Down Syndrome
Study Points to Novel Role for Microglia in Down Syndrome
Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.
Study Points to Novel Role for Microglia in Down Syndrome
Study Points to Novel Role for Microglia in Down Syndrome

Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.

Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.

mouse model
Blood Replacement Rescues Mice from Stroke Damage
Blood Replacement Rescues Mice from Stroke Damage
Amanda Heidt | Aug 31, 2020
When mice that had suffered a stroke were given blood from a healthy donor, they experienced less tissue and neurological damage.
Malaria Parasites’ Biological Clocks Coordinate Cell Destruction
Malaria Parasites’ Biological Clocks Coordinate Cell Destruction
Abby Olena | May 14, 2020
Two studies show that Plasmodium—the genus of protozoans that cause malaria—have an internal sense of time that synchronizes with their host’s circadian rhythms and allows the parasites to collectively attack blood cells.
Quasi-Lymphatic System in the Rodent Eye Clears Waste
Quasi-Lymphatic System in the Rodent Eye Clears Waste
Abby Olena | Apr 16, 2020
Two rodent models of glaucoma have defects in the waste drainage system.
Image of the Day: Muting Muscle Spasms
Image of the Day: Muting Muscle Spasms
Amy Schleunes | Apr 16, 2020
Nimodipine, a drug used to treat brain hemorrhages, alleviates spasticity in mice after spinal cord injuries.
Symptoms in ALS Mouse Model Improve with CRISPR Base Editing
Symptoms in ALS Mouse Model Improve with CRISPR Base Editing
Abby Olena | Apr 10, 2020
Researchers slowed disease progression in the mice by injecting two different viral vectors, each containing one part of the DNA encoding the Cas9 protein, to edit the causative gene.
Image of the Day: A Mouse Brain Slice Becomes Art
Image of the Day: A Mouse Brain Slice Becomes Art
Amy Schleunes | Apr 1, 2020
A fluorescent image of murine hippocampal cells is the winning microscopy image from more than 400 submissions from 65 countries for Olympus’s 2019 Image of the Year Award.
Animal Facilities Make Tough Decisions as Pandemic Closes Labs
Animal Facilities Make Tough Decisions as Pandemic Closes Labs
Abby Olena | Mar 27, 2020
Many researchers have stopped breeding mice, reduced the size of colonies, and established contingency plans in case animal care staff get sick.
Image of the Day: Stomach Stem Cells
Image of the Day: Stomach Stem Cells
Amy Schleunes | Feb 13, 2020
A mouse model demonstrates that mutations in stomach stem cells can drive gastric cancer growth.
Early Embryo Models Generated from Mouse Stem Cells
Early Embryo Models Generated from Mouse Stem Cells
Abby Olena | Oct 17, 2019
Extended pluripotent stem cells from mice can self-organize to form blastocyst-like structures called blastoids that enable a closer look at early mammalian development.