Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder
Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder
A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.
Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder
Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder

A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.

A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.

mouse model
Exercising During Pregnancy Protects Mouse Offspring
Exercising During Pregnancy Protects Mouse Offspring
Jack J. Lee | Aug 1, 2021
Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.
Mammals Can Use Their Intestines to Breathe
Mammals Can Use Their Intestines to Breathe
Abby Olena | May 14, 2021
Researchers show that both mice and pigs are capable of oxygenating their blood via the colon—a capacity that, if shared by humans, could be leveraged in the clinic to minimize the need for mechanical ventilation.
Cones Derived from Human Stem Cells Help Mice See: Study
Cones Derived from Human Stem Cells Help Mice See: Study
Marcus A. Banks | Apr 23, 2021
Researchers insert functioning cone photoreceptors into the retinas of mice with advanced eye disease, improving their vision.
Early Training Forestalls Motor, Memory Difficulties in Mouse Model of Rett Syndrome
Early Training Forestalls Motor, Memory Difficulties in Mouse Model of Rett Syndrome
Laura Dattaro | Mar 29, 2021
Manipulating the activity of neurons active during training had similar effects on the mice’s behavior.
A Tweak to Immune Cells Reverses Aging in Mice
A Tweak to Immune Cells Reverses Aging in Mice
Abby Olena | Jan 20, 2021
Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.
SARS-CoV-2 Exits Cells Via Lysosomes
SARS-CoV-2 Exits Cells Via Lysosomes
Abby Olena | Nov 13, 2020
A study finds that β-coronaviruses don’t use the normal secretory pathway, a possible explanation for some aspects of COVID-19 pathology.
Study Points to Novel Role for Microglia in Down Syndrome
Study Points to Novel Role for Microglia in Down Syndrome
Catherine Offord | Oct 6, 2020
Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.
Blood Replacement Rescues Mice from Stroke Damage
Blood Replacement Rescues Mice from Stroke Damage
Amanda Heidt | Aug 31, 2020
When mice that had suffered a stroke were given blood from a healthy donor, they experienced less tissue and neurological damage.
Malaria Parasites’ Biological Clocks Coordinate Cell Destruction
Malaria Parasites’ Biological Clocks Coordinate Cell Destruction
Abby Olena | May 14, 2020
Two studies show that Plasmodium—the genus of protozoans that cause malaria—have an internal sense of time that synchronizes with their host’s circadian rhythms and allows the parasites to collectively attack blood cells.
Quasi-Lymphatic System in the Rodent Eye Clears Waste
Quasi-Lymphatic System in the Rodent Eye Clears Waste
Abby Olena | Apr 16, 2020
Two rodent models of glaucoma have defects in the waste drainage system.
Image of the Day: Muting Muscle Spasms
Image of the Day: Muting Muscle Spasms
Amy Schleunes | Apr 16, 2020
Nimodipine, a drug used to treat brain hemorrhages, alleviates spasticity in mice after spinal cord injuries.
Symptoms in ALS Mouse Model Improve with CRISPR Base Editing
Symptoms in ALS Mouse Model Improve with CRISPR Base Editing
Abby Olena | Apr 10, 2020
Researchers slowed disease progression in the mice by injecting two different viral vectors, each containing one part of the DNA encoding the Cas9 protein, to edit the causative gene.
Image of the Day: A Mouse Brain Slice Becomes Art
Image of the Day: A Mouse Brain Slice Becomes Art
Amy Schleunes | Apr 1, 2020
A fluorescent image of murine hippocampal cells is the winning microscopy image from more than 400 submissions from 65 countries for Olympus’s 2019 Image of the Year Award.
Animal Facilities Make Tough Decisions as Pandemic Closes Labs
Animal Facilities Make Tough Decisions as Pandemic Closes Labs
Abby Olena | Mar 27, 2020
Many researchers have stopped breeding mice, reduced the size of colonies, and established contingency plans in case animal care staff get sick.
Image of the Day: Stomach Stem Cells
Image of the Day: Stomach Stem Cells
Amy Schleunes | Feb 13, 2020
A mouse model demonstrates that mutations in stomach stem cells can drive gastric cancer growth.
Early Embryo Models Generated from Mouse Stem Cells
Early Embryo Models Generated from Mouse Stem Cells
Abby Olena | Oct 17, 2019
Extended pluripotent stem cells from mice can self-organize to form blastocyst-like structures called blastoids that enable a closer look at early mammalian development.
Gut Microbe Linked to Nonalcoholic Fatty Liver Disease
Gut Microbe Linked to Nonalcoholic Fatty Liver Disease
Abby Olena | Sep 19, 2019
Researchers find strains of the bacterium Klebsiella pneumoniae that produce high levels of alcohol in 60 percent of patients with the condition.