Scientist hunched over a lab workbench in exhaustion
Neurotransmitter Buildup May Be Why Your Brain Feels Tired
Performing complex cognitive tasks leads to glutamate accumulating in a key region of the brain, a study finds, which could explain why mental labor is so exhausting.
Neurotransmitter Buildup May Be Why Your Brain Feels Tired
Neurotransmitter Buildup May Be Why Your Brain Feels Tired

Performing complex cognitive tasks leads to glutamate accumulating in a key region of the brain, a study finds, which could explain why mental labor is so exhausting.

Performing complex cognitive tasks leads to glutamate accumulating in a key region of the brain, a study finds, which could explain why mental labor is so exhausting.

multiple sclerosis
Epstein-Barr virus EBV, a herpes virus which causes infectious mononucleosis and Burkitt's lymphoma isolated on black background. 3D illustration
Epstein-Barr Virus Causes Multiple Sclerosis: Study
Christie Wilcox | Jan 13, 2022 | 3 min read
Experts say new research provides strong evidence that a common herpesvirus can trigger the chronic inflammatory disease.
neurological disorder, brain disease, Q&A, Alzheimer's disease, Parkinson's disease, multiple sclerosis, motor neuron disease, neurodegeneration, blood-brain barrier, sex
Sex of Human Cells Matters in Studying Neurological Disease
Amanda Heidt | Mar 18, 2021 | 5 min read
Authors of a new review urge researchers to consider how the chromosomal sex of a cell affects experiments in research on neurodegeneration.
Christmas background
Helping the Immune System Keep its Cool
Aparna Nathan | 3 min read
Researchers found that lowering the temperature alleviates autoimmunity in mice.
herpes herpesvirus ms multiple sclerosis
Type of Herpes Virus Tied to Multiple Sclerosis
Katarina Zimmer | Jan 10, 2020 | 5 min read
A study of 16,000 people suggests that human herpesvirus 6A is a risk factor for developing multiple sclerosis, reinvigorating a neglected hypothesis that the virus could be involved in triggering the disease.
ms multiple sclerosis autoimmune disease pregnancy t cells clones
MS Relief During Pregnancy Tied to Changes in T Cell Types
Ashley P. Taylor | Nov 15, 2019 | 3 min read
Many dominant T cell variants decline during pregnancy and reappear afterward, possibly explaining why relapses of the autoimmune disease are less common when women are expecting.
Biomarkers on the Brain: From Sequencing to Functional Imaging
Biomarkers on the Brain: From Sequencing to Functional Imaging
The Scientist Creative Services Team | 2 min read
An expert panel will discuss biomarker development for brain disorders and considerations for their clinical use.
Pelizaeus-Merzbacher disease neural stem cell transplantation
Neural Stem Cell Transplantation Crawls Toward the Clinic
Ashley P. Taylor | Oct 29, 2019 | 5+ min read
Several early-stage clinical trials indicate that implanting patients with the cells is safe. But whether they can alleviate neurological problems remains to be seen.
northwestern memorial hospital hsct hematopoietic stem cell clinical trial multiple sclerosis ms selma blair richard burt
Northwestern University Stem Cell Therapy Clinic Closes Abruptly
Katarina Zimmer | Sep 6, 2019 | 5 min read
A Chicago-based center that has long operated a clinical trial program for stem cell therapies, has stopped recruiting further patients as its chief, Richard Burt, leaves for a research sabbatical.
microbiome
Do Commensal Microbes Stoke the Fire of Autoimmunity?
Amanda B. Keener | Jun 1, 2019 | 5+ min read
Molecules produced by resident bacteria and their hosts may signal immune cells to attack the body’s own tissues.
march 2019 the scientist profile
Master Decoder: A Profile of Kári Stefánsson
Anna Azvolinsky | Mar 1, 2019 | 5+ min read
A neurologist by training, Stefánsson founded Iceland-based deCODE Genetics to explore what the human genome can tell us about disease and our species’ evolution.
Infographic: Human Endogenous Retroviruses and Disease
Katarina Zimmer | Jan 1, 2019 | 3 min read
Human endogenous retroviruses that colonized vertebrate DNA millions of years ago have long been dismissed as junk DNA, but researchers now know that they may play important roles in cancer, neurodegeneration, and other ailments.
Can Viruses in the Genome Cause Disease?
Katarina Zimmer | Jan 1, 2019 | 5+ min read
Clinical trials that target human endogenous retroviruses to treat multiple sclerosis, ALS, and other ailments are underway, but many questions remain about how these sequences may disrupt our biology.
Image of the Day: Telling Scans
Aggie Mika | Oct 16, 2017 | 1 min read
In children’s brain scans, scientists uncovered signs of multiple sclerosis before the kids showed any symptoms of the disease.
Multiple Sclerosis: Is Yawning a Warning?
Benjamin Skuse | Sep 1, 2016 | 4 min read
Neuropsychologist Simon Thompson found a possible link between yawning and multiple sclerosis. So what better way to get under the skin of his research than volunteering to take part in one of his experiments?
Toward Targeted Therapies for Autoimmune Disorders
Lawrence Steinman | Jun 1, 2016 | 5+ min read
Training the immune system to cease fire on native tissues could improve outcomes for autoimmune patients, but clinical progress has been slow.
B Cells Can Drive Inflammation in MS
Anna Azvolinsky | Oct 21, 2015 | 3 min read
Researchers identify a subset of proinflammatory cytokine-producing B cells that may spark multiple sclerosis-related inflammation.  
New Hope for Alzheimer’s Blood Test
Jef Akst | Oct 19, 2015 | 1 min read
Using autoantibodies as biomarkers, researchers could soon identify people at the highest risk of developing neurodegenerative diseases much earlier than existing methods.
Melatonin for MS?
Karen Zusi | Sep 11, 2015 | 2 min read
Improvements in multiple sclerosis symptoms correlate with higher levels of the sleep hormone, a study finds.
Novartis Buys Rights to GSK MS Drug for $1 Billion
Kerry Grens | Aug 24, 2015 | 1 min read
The multiple sclerosis treatment has yet to be tested in Phase 3 clinical trials.