Red blood vessels that decrease in diameter as they radiate outward are pictured on a pink and white surface
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
ABOVE: ISTOCK.COM, UGREEN
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier

RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.

RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.

ABOVE: ISTOCK.COM, UGREEN
oligonucleotides
Breakthrough Prizes Recognize Aneuploidy Researcher, Biochemist
Catherine Offord | Oct 18, 2018
This year’s winners also include the developers of nusinersen, an oligonucleotide therapeutic for spinal muscular atrophy.
Custom-Made Molecules
Ruth Williams | Aug 20, 2017
A new prototype machine can make the biological molecules of one’s choice from digital DNA sequences.
FDA Approves First Treatment for Spinal Muscular Atrophy
Ben Andrew Henry | Dec 27, 2016
The oligonucleotide therapeutic will soon be available in the U.S.
Oligonucleotide Therapeutics Near Approval
Catherine Offord | Dec 1, 2016
Successful late-stage clinical trials could mark the maturation of a new drug development platform, but the path to commercialization is not without hurdles.
Speaking of Neuroscience
Jef Akst, Mary Beth Aberlin | Nov 18, 2016
A selection of notable quotes from the annual Society for Neuroscience meeting