Cancer May Be Driven by DNA Outside of Chromosomes
Cancer May Be Driven by DNA Outside of Chromosomes
In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.
Cancer May Be Driven by DNA Outside of Chromosomes
Cancer May Be Driven by DNA Outside of Chromosomes

In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.

In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.

oncogene
Infographic: The Role of Extrachromosomal DNA in Cancer
Infographic: The Role of Extrachromosomal DNA in Cancer
Paul Mischel | Apr 1, 2021
Researchers are uncovering how circular bits of DNA found in some cancer cells can help tumors evolve and kill.
p53 as an Immune System Modulator in Cancer
p53 as an Immune System Modulator in Cancer
The Scientist Creative Services Team | Sep 25, 2020
Best known as a cell cycle regulator, p53 signaling mediates pro and anti-cancer immune responses as well
Philip Leder, Who Deciphered Amino Acid Sequences, Dies
Philip Leder, Who Deciphered Amino Acid Sequences, Dies
Ashley Yeager | Feb 12, 2020
The Harvard Medical School researcher’s work on the genetic basis of protein coding and production led him to make groundbreaking discoveries in immunology, molecular biology, and cancer genetics.
First Direct-to-Consumer BRCA Test Authorized by FDA
First Direct-to-Consumer BRCA Test Authorized by FDA
Kerry Grens | Mar 6, 2018
The agency gave personal genomics company 23andMe the green light to screen samples for breast cancer–related genetic mutations.
Study Raises Questions About Patient-Derived Xenografts
Study Raises Questions About Patient-Derived Xenografts
Ashley P. Taylor | Oct 10, 2017
When transplanted into mice, tumor genomes evolve differently than they do in patients, study finds.
Pradeep Chaluvally-Raghavan: Curious about Cancer
Pradeep Chaluvally-Raghavan: Curious about Cancer
Jef Akst | Apr 1, 2016
Instructor, Department of Systems Biology, University of Texas MD Anderson Cancer Center. Age: 38
MYC Helps Cancer Hide
MYC Helps Cancer Hide
Anna Azvolinsky | Mar 10, 2016
The transcriptional regulator dampens the immune system’s ability to elicit an antitumor response, a study shows.
Influential Cancer Biologist Dies
Influential Cancer Biologist Dies
Kerry Grens | Aug 24, 2015
Chris Marshall, who pieced together a critical signaling pathway involved in cancer, has passed away at age 66.
Two-Faced RNAs
Two-Faced RNAs
Kerry Grens | Apr 1, 2015
The same microRNAs can have opposing roles in cancer.
Setbacks and Great Leaps
Setbacks and Great Leaps
Sue Armstrong | Apr 1, 2015
The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.
Professional Marksman
Professional Marksman
Anna Azvolinsky | Apr 1, 2015
Charles Sawyers, who began his research career just as the genetic details of human oncogenes were emerging, codeveloped Gleevec, the quintessential targeted cancer therapy.
Resisting Cancer
Resisting Cancer
George Klein | Apr 1, 2015
If one out of three people develops cancer, that means two others don’t. Understanding why could lead to insights relevant to prevention and treatment.
Book Excerpt from <em>p53</em>
Book Excerpt from p53
Sue Armstrong | Mar 31, 2015
In Chapter 12, "Of Mice and Men," author Sue Armstrong recounts the point at which researchers moved from working with p53 in tissue culture to studying the gene in animal models.
The Origins of Oversized Chromosomes
The Origins of Oversized Chromosomes
Molly Sharlach | Nov 12, 2014
Researchers reconstruct the formation of the giant neochromosomes that contribute to some cancers.
A Cancer-Heart Disease Link
Cristina Luiggi | Dec 22, 2011
Mutations known to increase the risk of developing ovarian and breast cancer may also make carriers susceptible to heart failure.
News from Cell
Cristina Luiggi | Dec 9, 2011
Some of the highlights from this year’s American Society for Cell Biology meeting, held earlier this week
Myc, Nicked
Richard P. Grant | Jan 1, 2011
Editor's Choice in Developmental Biology