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Ovarian Proteins That Last a Lifetime Help Maintain Egg Cells for Years
Long-lived proteins in the mouse ovary may help preserve fertility well into adulthood, providing insights into ovarian aging. 
Ovarian Proteins That Last a Lifetime Help Maintain Egg Cells for Years
Ovarian Proteins That Last a Lifetime Help Maintain Egg Cells for Years

Long-lived proteins in the mouse ovary may help preserve fertility well into adulthood, providing insights into ovarian aging. 

Long-lived proteins in the mouse ovary may help preserve fertility well into adulthood, providing insights into ovarian aging. 

oocyte

illustration of human oocyte
Mammalian Oocytes Store mRNA in Newly Found Membraneless Structure
Alejandra Manjarrez, PhD | Oct 20, 2022 | 3 min read
The findings answer the longstanding question of where these cells hold the mRNA needed to cope with the transcriptional halt preceding meiosis.
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How Immature Egg Cells in Ovaries Resist Aging
Shafaq Zia | Aug 4, 2022 | 3 min read
The cells’ mitochondria skip a key metabolic reaction that takes place in other cells in the body, a study finds.
Eight Proteins Turn Mouse Stem Cells into Egglike Cells
Ashley Yeager | Dec 16, 2020 | 3 min read
The identification of the transcription factors that elicit oocyte growth will aid reproductive biology research and might help women with fertility issues, scientists say.  
Single-Cell Analysis of Ovarian Cortex Fails to Find Stem Cells
Amy Schleunes | Mar 6, 2020 | 5 min read
The controversial oogonial stem cells eluded a team of Swedish researchers who mapped high-quality tissue samples of the human ovary, prompting more questions about the cells’ existence.  
Baby Born from Egg that Was Matured and Frozen in the Lab
Catherine Offord | Feb 19, 2020 | 2 min read
A cancer patient who underwent the new fertility preservation procedure successfully gave birth five years after her immature eggs were collected.
A Brush with Inheritance, 1878
Catherine Offord | Feb 1, 2018 | 2 min read
Lampbrush chromosomes, first observed in the 19th century, still offer an unparalleled glimpse into how genetic information is organized in the cell.
New Techniques Detail Embryos’ First Hours and Days
Jef Akst | Dec 1, 2017 | 10+ min read
New technologies reveal the dynamic changes in mouse and human embryos during the first week after fertilization.
Infographic: How Embryos Take Control of Their Own Development
Jef Akst | Nov 30, 2017 | 3 min read
The switch from maternal factors involves dynamic reprogramming of the zygotic genome.
Three-Parent IVF Advances
Anna Azvolinsky | Nov 30, 2016 | 4 min read
Differences in the replicative advantages conferred by some mitochondrial DNA haplotypes have implications for mitochondrial replacement therapy, researchers report. 
Week in Review: October 17–21
Jef Akst | Oct 20, 2016 | 2 min read
Report finds that pathologist involved in anonymous defamation case committed multiple acts of misconduct; growing eggs from stem cells; neutrophils’ role in metastasis; convergent evolution in birds
From Stem Cell to Oocyte In a Dish
Anna Azvolinsky | Oct 17, 2016 | 4 min read
For the first time, scientists generate functional mouse eggs from stem cells in culture.
A Scrambled Mess
Karen Schindler | May 1, 2016 | 10+ min read
Why do so many human eggs have the wrong number of chromosomes?
Next Generation: Sperm-Catching Beads
Anna Azvolinsky | Apr 27, 2016 | 3 min read
Sperm-binding, peptide–coated beads work as an implantable contraception device in mice and as a means of selecting human sperm for assisted reproduction techniques, researchers show. 
Oocytes and Obesity
Ashley P. Taylor | Feb 10, 2015 | 3 min read
Eggs from excessively overweight mothers suffer mitochondrial damage that can be averted with pharmacological intervention, a mouse study finds. 
Gravity Determines Cell Size
Abby Olena, PhD | Oct 29, 2013 | 2 min read
Researchers show that cells may have evolved to be small because of gravitational forces.
Why Women’s Eggs Don’t Last
Kate Yandell | Feb 13, 2013 | 3 min read
As reproductive tissues age, DNA repair mechanisms become less efficient, causing genomic damage to accumulate.
Mouse Eggs Made with Stem Cells
Dan Cossins | Oct 4, 2012 | 3 min read
Researchers claim to have successfully transformed stem cells into viable mouse oocytes that produced healthy, fertile pups.
Ovarian Stem Cell Debate
Ed Yong | Jul 9, 2012 | 3 min read
Opinion is divided on a new paper showing that adult ovaries do not contain egg-making stem cells, contrary to the findings of two recent studies that themselves appeared to overturn longstanding dogma.
Growing Human Eggs
Hannah Waters | Jun 1, 2012 | 2 min read
Germline stem cells discovered in human ovaries can be cultured into fresh eggs.
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