A micrograph of the prion-like state of a protein called Pus4
Protein Mediates Non-Genetic Inheritance of Growth Strategies
An RNA-modifying enzyme passed to daughter cells during budding allows yeast cells to switch between faster- and slower-growing phenotypes.
ABOVE: eLife, 10:e69199, 2021
Protein Mediates Non-Genetic Inheritance of Growth Strategies
Protein Mediates Non-Genetic Inheritance of Growth Strategies

An RNA-modifying enzyme passed to daughter cells during budding allows yeast cells to switch between faster- and slower-growing phenotypes.

An RNA-modifying enzyme passed to daughter cells during budding allows yeast cells to switch between faster- and slower-growing phenotypes.

ABOVE: eLife, 10:e69199, 2021

prions

micrograph showing red aggregating protein in mouse neurons
Citing Safety, French Institutions Temporarily Halt Prion Research
Annie Melchor | Jul 28, 2021
The three-month moratorium comes after a former prion researcher was diagnosed with Creutzfeldt-Jakob disease.
Detecting Protein Clumps
Ruth Williams | Feb 1, 2018
A synthetic genetic tool called yTRAP allows high-throughput detection of protein aggregates in cells.
 
Prions Found in Skin of Creutzfeldt-Jakob Patients
Jef Akst | Nov 23, 2017
Infectious protein aggregates from the skin of human patients can cause disease in mice.
Bacterial Protein Acts as Prion in Yeast and E. coli
Jef Akst | Jan 16, 2017
Clostridium botulinum produces a transcription factor that can aggregate and self-propagate a prion-like form, leading to genome-wide changes in gene expression in E. coli, according to a study.
Blood Tests for Prion Disease
Joshua A. Krisch | Dec 21, 2016
Two studies describe methods for detecting these misfolded proteins in human blood samples.
Protein Folding Pioneer Dies
Kerry Grens | Oct 28, 2016
Susan Lindquist of MIT and the Whitehead Institute broke scientific ground on prions and heat shock proteins.
Week in Review: September 5–9
Jef Akst | Sep 8, 2016
Environmental magnetite in the human brain; prion structure takes shape; watching E. coli evolve in real time; learning from others’ behavior 
First Glimpse at Infectious Prion Shape
Abby Olena | Sep 8, 2016
The preliminary structure of the misfolded protein that causes mad cow disease and Creutzfeldt-Jakob disease looks like a coiled mattress spring.
Prions in Plants?
Tanya Lewis | Apr 26, 2016
A plant protein that behaves like a prion when inserted into yeast could enable a form of botanical memory, a study suggests.
Fearless about Folding
Anna Azvolinsky | Jan 1, 2016
Susan Lindquist has never shied away from letting her curiosity guide her research career.
Esteemed Virologist Dies
Karen Zusi | Dec 7, 2015
Richard Johnson, a pioneer in research on central nervous system infections, died last month at age 84.
Can Amyloid Spread Between Brains?
Jef Akst | Sep 9, 2015
A study of deceased patients who received injections of cadaver-derived growth hormone hints at the possible transmissibility of Alzheimer’s disease. 
Neurodegeneration’s Spread
Ashley P. Taylor | Aug 3, 2014
Researchers show that pathogenic protein aggregates that accumulate within neurons and are a hallmark of Huntington’s disease can propagate from cell to cell.
Protein Clumps Spread Inflammation
Kate Yandell | Jun 22, 2014
ASC specks—protein aggregations that drive inflammation—are released from dying immune cells, expanding the reach of a defense response.
Capsule Reviews
Bob Grant | May 1, 2014
Madness and Memory, Promoting the Planck Club, The Carnivore Way, and The Tale of the Dueling Neurosurgeons
Prions Important for Memories
Kerry Grens | Feb 19, 2014
The formation of long-term memories employs the chain-forming habits of prions.  
Stranger than Fiction
Mary Beth Aberlin | Jan 1, 2014
Plant biology: You can't make this stuff up.
The Bright Side of Prions
Randal Halfmann | Jan 1, 2014
Associated with numerous neurological diseases, misfolded proteins may also play decisive roles in normal cellular functioning.
 
Contributors
Abby Olena and Tracy Vence | Jan 1, 2014
Meet some of the people featured in the January 2014 issue of The Scientist.