RNA Interference Comes of Age
RNA Interference Comes of Age
The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.
RNA Interference Comes of Age
RNA Interference Comes of Age

The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.

The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.

RNAi
Engineered Microbe in Bees’ Guts Fends off Deadly Varroa Mite
Engineered Microbe in Bees’ Guts Fends off Deadly Varroa Mite
Lisa Winter | Jan 31, 2020
The genetically modified bacteria spark an RNAi response in the parasite that leads to self-destruction—and perhaps a path to combatting colony collapse disorder.
2018 in Quotes
2018 in Quotes
Catherine Offord | Dec 24, 2018
From the effects of political upheaval on research to claims of gene-edited babies, the year has been a tumultuous one for the scientific community.
First RNAi Therapy Approved by FDA
First RNAi Therapy Approved by FDA
Kerry Grens | Aug 10, 2018
Alnylam’s patisiran interferes with the production of a mutated protein present in people with hereditary transthyretin amyloidosis.
RNA Interference Drug Excels in Clinical Trials to Treat Rare Disorder
RNA Interference Drug Excels in Clinical Trials to Treat Rare Disorder
Katarina Zimmer | Nov 3, 2017
If approved, patisiran will be the first RNAi therapeutic on the market. 
CRISPR System Targets RNA in Mammalian Cells
CRISPR System Targets RNA in Mammalian Cells
Anna Azvolinsky | Oct 4, 2017
Researchers engineer bacterial CRISPR-Cas13 to knock down RNA in mammalian cells.
Massive RNAi Screens Probe for Genes Important to Cancer
Massive RNAi Screens Probe for Genes Important to Cancer
Kerry Grens | Jul 26, 2017
Two freely available databases include data on hundreds of human cancer cell lines. 
Mammalian Immunity: What’s RNAi Got to Do with It?
Mammalian Immunity: What’s RNAi Got to Do with It?
Shawna Williams | Jul 21, 2017
A new study adds to the evidence that mammalian cells can use small interfering RNAs to defend against viruses, but questions remain about physiological importance.
First RNAi Insecticide Approved
First RNAi Insecticide Approved
Aggie Mika | Jun 27, 2017
This month, the EPA registered four products that include RNA interference technology intended to control corn rootworms. 
The RNA Age: A Primer
The RNA Age: A Primer
Ruth Williams | May 11, 2017
Our guide to all known forms of RNA, from cis-NAT to vault RNA and everything in between.
RNAi’s Future in Drug-Target Screening
RNAi’s Future in Drug-Target Screening
Catherine Offord | Apr 16, 2017
A recent CRISPR study contradicted years of RNA interference research on a well-studied cancer drug target. But is it the last nail in the coffin for RNAi as a screening tool? 
RNA Interference Between Kingdoms
RNA Interference Between Kingdoms
Kerry Grens | Feb 1, 2017
Plants and fungi can use conserved RNA interference machinery to regulate each other’s gene expression—and scientists think they can make use of this phenomenon to create a new generation of pesticides.
Oligonucleotide Therapeutics Near Approval
Oligonucleotide Therapeutics Near Approval
Catherine Offord | Dec 1, 2016
Successful late-stage clinical trials could mark the maturation of a new drug development platform, but the path to commercialization is not without hurdles.
Questions Over <em>C. elegans</em> Life Span Factors
Questions Over C. elegans Life Span Factors
Catherine Offord | Jun 1, 2016
A recent paper challenges earlier findings that germline factors expressed in normal body cells influence life span in C. elegans.
Gut Bacteria for Insect RNAi
Gut Bacteria for Insect RNAi
Ruth Williams | Jun 1, 2016
Lacing insect food with microbes encoding double-stranded RNAs can suppress insect gene expression.
Gut Bacteria Vectors
Gut Bacteria Vectors
Ruth Williams | May 31, 2016
Researchers mix bacteria genetically engineered to express double-stranded RNA into insect food.
Dial It Up, Dial It Down
Dial It Up, Dial It Down
Kelly Rae Chi | Mar 1, 2016
Newer CRISPR tools for manipulating transcription will help unlock noncoding RNA’s many roles.
Funding Ban for Plant Biologist
Funding Ban for Plant Biologist
Kerry Grens | Jan 26, 2016
Olivier Voinnet, who has corrected and retracted several papers, cannot receive Swiss government grants for three years.
Report: Plant Biologist Guilty of Misconduct
Report: Plant Biologist Guilty of Misconduct
Tracy Vence | Jul 10, 2015
Investigators find that RNAi researcher Olivier Voinnet willfully misrepresented data published in several journals.
Improving Crops with RNAi
Improving Crops with RNAi
Narender Nehra and Nigel Taylor | Jun 1, 2015
RNA interference is proving to be a valuable tool for agriculture, allowing researchers to develop pathogen-resistant and more-nutritious crops.