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RNA Interference Comes of Age
The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.
RNA Interference Comes of Age
RNA Interference Comes of Age

The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.

The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.

RNAi

Engineered Microbe in Bees’ Guts Fends off Deadly Varroa Mite
Lisa Winter | Jan 31, 2020
The genetically modified bacteria spark an RNAi response in the parasite that leads to self-destruction—and perhaps a path to combatting colony collapse disorder.
2018 in Quotes
Catherine Offord | Dec 24, 2018
From the effects of political upheaval on research to claims of gene-edited babies, the year has been a tumultuous one for the scientific community.
First RNAi Therapy Approved by FDA
Kerry Grens | Aug 10, 2018
Alnylam’s patisiran interferes with the production of a mutated protein present in people with hereditary transthyretin amyloidosis.
RNA Interference Drug Excels in Clinical Trials to Treat Rare Disorder
Katarina Zimmer | Nov 3, 2017
If approved, patisiran will be the first RNAi therapeutic on the market. 
CRISPR System Targets RNA in Mammalian Cells
Anna Azvolinsky | Oct 4, 2017
Researchers engineer bacterial CRISPR-Cas13 to knock down RNA in mammalian cells.
Massive RNAi Screens Probe for Genes Important to Cancer
Kerry Grens | Jul 26, 2017
Two freely available databases include data on hundreds of human cancer cell lines. 
Mammalian Immunity: What’s RNAi Got to Do with It?
Shawna Williams | Jul 21, 2017
A new study adds to the evidence that mammalian cells can use small interfering RNAs to defend against viruses, but questions remain about physiological importance.
First RNAi Insecticide Approved
Aggie Mika | Jun 27, 2017
This month, the EPA registered four products that include RNA interference technology intended to control corn rootworms. 
The RNA Age: A Primer
Ruth Williams | May 11, 2017
Our guide to all known forms of RNA, from cis-NAT to vault RNA and everything in between.
RNAi’s Future in Drug-Target Screening
Catherine Offord | Apr 16, 2017
A recent CRISPR study contradicted years of RNA interference research on a well-studied cancer drug target. But is it the last nail in the coffin for RNAi as a screening tool? 
RNA Interference Between Kingdoms
Kerry Grens | Feb 1, 2017
Plants and fungi can use conserved RNA interference machinery to regulate each other’s gene expression—and scientists think they can make use of this phenomenon to create a new generation of pesticides.
Oligonucleotide Therapeutics Near Approval
Catherine Offord | Dec 1, 2016
Successful late-stage clinical trials could mark the maturation of a new drug development platform, but the path to commercialization is not without hurdles.
Questions Over C. elegans Life Span Factors
Catherine Offord | Jun 1, 2016
A recent paper challenges earlier findings that germline factors expressed in normal body cells influence life span in C. elegans.
Gut Bacteria for Insect RNAi
Ruth Williams | Jun 1, 2016
Lacing insect food with microbes encoding double-stranded RNAs can suppress insect gene expression.
Gut Bacteria Vectors
Ruth Williams | May 31, 2016
Researchers mix bacteria genetically engineered to express double-stranded RNA into insect food.
Dial It Up, Dial It Down
Kelly Rae Chi | Mar 1, 2016
Newer CRISPR tools for manipulating transcription will help unlock noncoding RNA’s many roles.
Funding Ban for Plant Biologist
Kerry Grens | Jan 26, 2016
Olivier Voinnet, who has corrected and retracted several papers, cannot receive Swiss government grants for three years.
Report: Plant Biologist Guilty of Misconduct
Tracy Vence | Jul 10, 2015
Investigators find that RNAi researcher Olivier Voinnet willfully misrepresented data published in several journals.
Improving Crops with RNAi
Narender Nehra and Nigel Taylor | Jun 1, 2015
RNA interference is proving to be a valuable tool for agriculture, allowing researchers to develop pathogen-resistant and more-nutritious crops.