salmonella bacteria 3d illustration
Salmonella Injection Helps the Mouse Immune System Kill Tumors
Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.
ABOVE: © ISTOCK.COM, urfinguss
Salmonella Injection Helps the Mouse Immune System Kill Tumors
Salmonella Injection Helps the Mouse Immune System Kill Tumors

Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.

Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.

ABOVE: © ISTOCK.COM, urfinguss

tumor

Illustration showing how following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano- particles near tumors in mice.
Infographic: Salmonella Shuttle Tumor Antigens to Immune Cells
Dan Robitzski | May 16, 2022
Nanoparticle-coated bacteria carry cancer-derived proteins to dendritic cells, enabling the immune system to launch a response in a mouse model.
Diffuse star-like shapes with regions in purple, green, and both colors overlapped.
Tumor Cells on Brink of Death May Trigger Metastasis
Alejandra Manjarrez | Mar 25, 2022
A new study reports that human colon cancer cells at imminent risk of death can instead develop characteristics needed to colonize new parts of the body.
The Future of Cancer Diagnosis with Nanopore Sequencing Technology
The Potential of Nanopore Sequencing Technology in Cancer Diagnosis
The Scientist Creative Services Team | May 11, 2022
In this webinar, Mashiat Mimosa will discuss the potential of a new sequencing method that detects glioma tumors in brain tissue.
A stained tissue sample of metastatic pancreatic cancer
Tetanus Immunity Protects Mice Against Pancreatic Cancer
Amanda Heidt | Mar 24, 2022
Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.
Tumor microbiome composite
Could Cancer’s Microbiome Help Diagnose and Treat the Disease?
Jef Akst | Mar 14, 2022
A growing appreciation of the bacterial assemblages that live within tumors has researchers striving to understand and capitalize on their role.
Identifying Biomarkers to Guide Cancer Immunotherapy
Identifying Biomarkers to Guide Cancer Immunotherapy
The Scientist Creative Services Team | Mar 15, 2022
An expert panel will discuss the cutting-edge technologies they used to identify novel biomarkers that predict patient responses to immunotherapy.
Illustration showing microbial signatures of cancer in the body
Infographic: Putting Cancer’s Unique Microbiomes to Use
Jef Akst | Mar 14, 2022
From diagnosis to tracking treatment responses, bacteria and other microbes in the blood, gut, and tumors of cancer patients may provide helpful hints for improving their care.
A photo of a triple-negative breast cancer cell
A Fasting-Mimicking Diet Thwarts Breast Cancer in Mice
Devin A. Reese | Mar 1, 2022
Coupling a diet low in calories, sugar, and protein with existing cancer drugs treats triple-negative breast cancer in mice, and low blood glucose is associated with better cancer outcomes in human patients.
Finding CAR T Cells in Solid Tumors by Single-Cell Resolution
Finding CAR T Cells in Solid Tumors at Single-Cell Resolution
The Scientist Creative Services Team in collaboration with Miltenyi Biotec | Nov 12, 2021
Rita Pfeifer will discuss visualizing and quantifying CAR T-cell infiltration into solid tumors with 3-D light sheet fluorescence microscopy (LSFM).
black-and-white image of an open mouth
The Common Mouth Microbe That Keeps Popping Up in Tumors
David Adam | Dec 15, 2021
Lab studies link the oral bacteria Fusobacterium nucleatum to cancers from the gut to the head and neck. Could targeting the microbe tackle tumors?
A compilation of several images, including a dog, a blind mole rat, and cell micrographs
Our Favorite Cancer Stories of 2021
Amanda Heidt | Dec 9, 2021
This year revealed just how much scientists have learned about the disease, from how animals become naturally cancer-resistant to how tumor cells harness extracellular DNA to develop rapid drug resistance.
Undone Proteins Take Out Bladder Cancer
Roni Dengler, PhD | Jul 20, 2021
An unfolded protein found in human milk shows promise in early clinical trials to treat bladder cancer.
fingertips with pills on them
Over-the-Counter Antihistamines Could Help Against Cancer
Alejandra Manjarrez | Nov 24, 2021
The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.
A multicolored section of a fruit fly brain
Tumors Disrupt the Blood-Brain Barrier at a Distance
Abby Olena | Sep 9, 2021
Shoring up the tissues that separate neurons and other brain cells from the circulatory system in fruit flies and mice can prolong life in the presence of a tumor.
Advancing Cancer Biomarker Detection with Single Cell Proteomics
The Scientist Creative Services Team in Collaboration with IsoPlexis | May 31, 2021
An improved ELISA-based proteomics chip detects cytokines in single cell applications.
visualization of p53 protein interacting with its inhibitors MDM2 and MDMX
p53 Unleashes Endogenous Retroviruses to Tackle Tumors: Study
Marcus A. Banks | Jul 29, 2021
New experiments suggest the famous tumor-suppressing protein uses viral elements lingering in the genome to get cancerous cells to announce their presence to the immune system.
Infographic: Steps in Cancer Metastasis
Shawna Williams | Apr 1, 2021
It’s now thought that in many cases, cancer cells disseminate from the primary tumor site early on and lie dormant for long periods rather than only venturing out from primary tumors at an advanced stage.
Technique Talk: High-Throughput Drug Screening Using 3D Cell Culture
The Scientist Creative Services Team in collaboration with MilliporeSigma | May 5, 2021
In this workshop, learn how to use hydrogel 3D cell culture plates for streamlined 3D cell culture colony formation, imaging, metabolic read-out, and T cell-mediated tumor cell killing.
New Understanding of Metastasis Could Lead to Better Treatments
Shawna Williams | Apr 1, 2021
Recent insights, such as the recognition that disseminated cancer cells can lie dormant for years before seeding secondary tumors, suggest novel strategies for fighting metastatic disease.