Today's Lab

Tom Sargent remembers the day a student in his lab forgot to add boiling chips to phenol before firing up the heater on the distillation apparatus, and the panicked shouting and tearing off of the lab coat, goggles, gloves, and shoes that ensued when the phenol superheated and boiled over. "Fortunately he wasn't hurt," said Sargent, now chief of the section on vertebrate development at the National Institute of Child and Human Development, "but what a mess." Then, there was the time he hooked up

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These scenarios are thankfully a thing of the past. Technology and capitalism have together provided instruments and kits that have taken over tasks that back in the 1960s and '70s could occupy weeks to months, and as Sargent's stories show, were occasionally dangerous. The days of labeling your own nucleotides, distilling your own phenol, purifying your own enzymes, or even making your own buffers are long gone. Innovation, the commercialization of reagent production, and simple modern conveniences such as the microwave oven have transformed labs into more efficient and safer places to work.

Forever changing the face of personal computing in the laboratory was the LINC, Laboratory Instrument Computer, so-called to emphasize what this computer's place in the lab was to be—a computer to run instruments. The LINC's designer, Wes Clark, who describes himself as a "would-have-been physicist who got interested in computers," recognized the need for computers in the ...

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