New lung cells in early anaphaseNATIONAL INSTITUTES OF HEALTH
In some cancers, chromosomes are broken apart and stitched back together, resulting in tens to hundreds of spontaneous genomic rearrangements, contravening the model of slowly accumulating point mutations and more subtle chromosome rearrangements. The process, dubbed "chromothripsis," occurs in at least 2-3 percent of all cancers, across many subtypes, and is present in 25 percent of bone cancers.
P.J. Stephens, et al., "Massive genomic rearrangement acquired in a single catastrophic event during cancer development," Cell, 144:27-40, 2011.
Getting chromosome segregation right during mitosis is crucial to accurate cell division, and this delicate orchestration depends on the proper formation and localization of the kinetochore, a protein complex normally formed in the cell's centromere. New research shows that two ...
