Top 7 in immunology

A snapshot of the most highly ranked articles in immunology and related areas, from Faculty of 1000.

Written byEdyta Zielinska

| 3 min read

Save for Later

Listen with Speechify

0:00

3:00

Ulcerative colitisWIKIMEDIA COMMONS

1. Receptor-snatching

In addition to binding the CD80 and CD86 receptors on the surface of antigen presenting cells, impairing their ability to activate T cells, the CTLA-4 receptor on T helper cells can physically snatch away the receptors, demonstrating another mechanism by which this molecule may suppress immunity.

O.S. Qureshi et al., “Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4,” Science, 332:600-3, 2011. Evaluated by Lieping Chen, Yale Univ Sch of Med; Amnon Altman, La Jolla Inst for Allergy and Immunology; Oberdan Leo and Muriel Moser, U of Brussels, Belgium. Free F1000 Evaluation

2. TRIMming retroviral infections

TRIM5, a ubiquitin ligase that helps thwart retroviral infections, works by promoting innate immune signaling and acting as a pattern recognition receptor ...

Interested in reading more?

The Scientist ARCHIVES

Become a Member of

Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!

Join for free today

Already a member?

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

Edyta Zielinska
Edyta Zielinska was a senior editor at The Scientist from 2007 to 2013, where she worked closely with scientific illustrators to develop accompanying graphics to illuminate complex concepts.
View Full Profile