Ulcerative colitisWIKIMEDIA COMMONS
In addition to binding the CD80 and CD86 receptors on the surface of antigen presenting cells, impairing their ability to activate T cells, the CTLA-4 receptor on T helper cells can physically snatch away the receptors, demonstrating another mechanism by which this molecule may suppress immunity.
O.S. Qureshi et al., “Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4,” Science, 332:600-3, 2011. Evaluated by Lieping Chen, Yale Univ Sch of Med; Amnon Altman, La Jolla Inst for Allergy and Immunology; Oberdan Leo and Muriel Moser, U of Brussels, Belgium. Free F1000 Evaluation
2. TRIMming retroviral infections
TRIM5, a ubiquitin ligase that helps thwart retroviral infections, works by promoting innate immune signaling and acting as a pattern recognition receptor ...
