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Which Neurons Go to Sleep First in Humans? fMRI Can Tell

By linking blood flow patterns to bioelectric signals in the brains of sleeping volunteers, scientists are studying the order in which brain regions fall asleep and wake up.

Written byAlejandra Manjarrez, PhD
| 3 min read
Artistic representation of a brain depicted as a clock on a background with one half in dark blue with yellow stars and one half in light blue with clouds.
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In the last decades, science has taught us that the mammalian brain isn’t always entirely awake or asleep. Dolphins can swim with one hemisphere asleep while the other is alert, and some neurons in sleep-deprived rats can “switch off” while the animals are still awake. In humans, this so-called “local sleep,” in which specific neuronal populations take a nap while the rest of the brain is awake, has been more challenging to study, since the invasive methods used to track it in other mammals cannot be used on people.

A new study published July 21 in PNAS seems to have overcome this challenge. By simultaneously mapping human brain signals measured with two different methods (one with good temporal resolution and the other with good spatial resolution), the team pinpointed the waking or sleeping state of neuronal populations at the local level. The achievement made it possible to identify which brain ...

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Meet the Author

  • alejandra manjarrez

    Alejandra Manjarrez is a freelance science journalist who contributes to The Scientist. She has a PhD in systems biology from ETH Zurich and a master’s in molecular biology from Utrecht University. After years studying bacteria in a lab, she now spends most of her days reading, writing, and hunting science stories, either while traveling or visiting random libraries around the world. Her work has also appeared in Hakai, The Atlantic, and Lab Times.

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