Giannina Descalzi
Giannina Descalzi Studies the Factors Underlying Chronic Pain
The University of Guelph neuroscientist is scoping out the brain regions and genes that change as a consequence of pain that lasts for months or even years.
ABOVE: University of Guelph
Giannina Descalzi Studies the Factors Underlying Chronic Pain
Giannina Descalzi Studies the Factors Underlying Chronic Pain

The University of Guelph neuroscientist is scoping out the brain regions and genes that change as a consequence of pain that lasts for months or even years.

The University of Guelph neuroscientist is scoping out the brain regions and genes that change as a consequence of pain that lasts for months or even years.

ABOVE: University of Guelph

neurons

A model of a brain made of many stacked, thin layers of brightly-colored material.
Neurons Damaged in Dementia Recognize Interruptions to Patterns
Anna Napolitano | Mar 16, 2022
A new study reveals a network of neurons that, when disrupted, impairs adaptation to new circumstances in several types of dementia.
False color image of two Caenorhabditis elegans roundworms; blue on a black background
Mitochondrial Stress Is Passed Between Generations
Amanda Heidt | Dec 1, 2021
Researchers identified a novel mechanism by which chemically induced stress is “remembered” by the mitochondria of worms more than 50 generations after the original trigger.
The Brain Inside Out: Mapping the Nervous System Wiring
The Brain Inside Out: Mapping the Nervous System's Wiring
The Scientist Creative Services Team | Jan 25, 2022
An expert panel will describe their efforts to chart billions of neuronal connections and discuss how this data provides unparalleled insight into neuronal cell biology, signal processing, and behavior.
MUSCLE CONTROL: Researchers pinpoint how C. elegans (pictured) manages to expel food from its mouth.
The Science Behind How Roundworms Spit
Diana Kwon | Dec 1, 2021
By viewing countless hours of expectorating worms, researchers discover a unique way in which neurons control the movement of muscles.
The head of a tadpole is pictured. Its eye is black, but the rest of its head is various shades of green
Scientists Use Photosynthesis to Power an Animal’s Brain
Abby Olena | Oct 13, 2021
Injecting oxygen-generating algae into tadpoles allows brain activity to continue in the absence of oxygen, researchers find.
800x560 thumbnail image
Using Digital Spatial Profiling for Transcriptomic Analysis of Neuronal Subpopulations
The Scientist Creative Services Team in collaboration with Advanced Cell Diagnostics | Nov 12, 2021
Kit Fuhrman and Anushka Dikshit present how to obtain whole transcriptome data from spatially mapped neuron populations.
Image of nerve fibers shown in green and red
Neurons Simplify Visual Signals by Responding to Only One Retina
Anne N. Connor | Oct 1, 2021
Mice have neurons that connect to both eyes but only propagate the signal from one or the other, simplifying the information sent to the cerebral cortex.
Conceptual image of numbers
Is Your Brain Wired for Numbers?
Catherine Offord | Oct 1, 2021
Our perception of quantity, separate from counting or estimation of magnitude more generally, is foundational to human cognition, according to some neuroscientists.
Mapping Neuronal Gene Expression to Understand Pain
The Scientist Creative Services Team in collaboration with Advanced Cell Diagnostics | Jul 15, 2021
Ted Price, Diana Tavares-Ferreira, and Stephanie Shiers discuss how mapping gene expression at the neuronal level provides insight into pain mechanisms and anti-pain drug development.
Illustration of a brain on a clock with a figure of a man moving the clock arms
Human “Time Cells” Encode, Process Flow of Time
Anne N. Connor | Oct 1, 2021
Neurons in the hippocampus store information on the timing of experiences in addition to their content, helping to mediate sequential memory recall, a new study shows.
Photograph of a brown laboratory mouse
Experiment Gone Awry Suggests Novel Way to Combat Hypoxia
Phil Jaekl | Oct 1, 2021
While exploring suspended animation in mice, scientists discover how an enzyme can protect the brain from dangerously low levels of oxygen.
Central Nervous System Modeling with iPSC-Derived Cells
The Creative Services Team in collaboration with BrainXell | Jun 8, 2021
Bryan Black and Lucas Thal will discuss their experiences screening hiPSC-derived neural cells to understand chronic pain and neuroinflammation.
Illustration of a Macaque viewing patterns of dots on a screen
Infographic: Single-Cell Recordings Identify “Number Neurons”
Catherine Offord | Oct 1, 2021
Some nerve cells in the brains of macaques respond selectively to particular numbers, hinting at a specialized pathway for extracting information about numerical quantity.
Photograph of a waterfall
Falling Water, Rising Rocks, 1834
Catherine Offord | Oct 1, 2021
Intrigued by an optical illusion he experienced while traveling in Scotland, Robert Addams wrote what is now considered one of the definitive observational accounts of so-called motion aftereffects.
Gaining Biological Insights into Brain Development Using Single Cell Technologies
Gaining Biological Insights into Brain Development Using Single Cell Technologies
The Scientist Creative Services Team in collaboration with 10x Genomics | Apr 12, 2021
Richard Smith will discuss the importance of ionic flux in in utero neuronal development.
morphine drip
Morphine Tolerance Pathway Identified in Mice
David Adam | Sep 20, 2021
Prolonged exposure to morphine triggers cells in the spine to release signaling molecules that increase pain sensitivity and dull the relief of the drug. Blocking this activity could improve pain management.
illustration of a blue neuron lit with red
Neuron-Released Protein Can Set Off Inflammation: Study
Marcus A. Banks | Aug 19, 2021
Research in mice suggests that moderating nerve activity with drugs or electrical pulses could modify tissue immune responses, curtailing the chronic pain often associated with inflammatory conditions.
CRISPR Technologies for the New Era of Cell and Gene Therapy
The Scientist Creative Services Team | Nov 25, 2020
Experts will discuss how they use new CRISPR technologies to advance their cell and gene therapy research.
Hippocampal neurons are labeled in blue and purple on a black background
New Role for Leptin: Promoting Synapse Formation in Rat Neurons
Abby Olena | May 20, 2021
The hormone, which is well known for regulating appetite, appears to influence neuronal development—a finding that could shed light on disorders such as autism that involve dysfunctional synapse formation.