Will Delaying Vaccine Doses Cause a Coronavirus Escape Mutant?

With many millions of people waiting several weeks to receive a second COVID-19 vaccine dose in some countries, experts consider the possibility that SARS-CoV-2 could evolve vaccine resistance.

Written byChris Baraniuk
| 6 min read
escape mutant vaccine resistance covid-19 sars-cov-2 sars2 coronavirus pandemic evolution variants antibodies neutralizing

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The pandemic has entered a new phase. Millions of people around the world are now receiving their first dose of a COVID-19 vaccine each day. In a few countries, including the UK, millions will wait for up to 12 weeks before they receive their second dose. Vaccinating as many people as possible with initial doses before moving on to second doses is intended as the fastest means of inducing a good level of protection within the population. But some experts say they worry that this constitutes a giant experiment in viral evolution, where the potential consequences remain troublingly unclear.

Among those concerned is Paul Bieniasz, a virologist at the Rockefeller University. “Rolling out a partially effective vaccine regime in the peak of a highly prevalent viral epidemic is just not a great idea if one of your goals is to avoid vaccine resistance,” he says.

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Meet the Author

  • chris baraniuk

    Chris Baraniuk is a freelance science journalist based in Northern Ireland who contributes to The Scientist. He has covered biological and medical science for a range of publications, including the BBC, the BMJ, and Mosaic. He also writes about nature, climate change, and technology. His background in the humanities has long proved invaluable in his quest to bring science stories to people from all walks of life.

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