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The Mormons' religious beliefs have proven to be quite a boon for cancer epidemiologists. Members of the Church of Jesus Christ of Latter-day Saints, following religious tenets, have meticulously recorded their family trees for centuries. Recognizing the research value of such data, Mark Skolnick, chief scientific officer at Myriad Genetics Inc. in Salt Lake City, computerized those records at the church's family history library 25 years ago. Recently, researchers had high hopes that the data wo

With true success stories in cancer treatment so rare, the flood of recent papers validating the 1998 Food and Drug Administration approval of Herceptin (trastuzumab) stands out.1-3 In a broader sense, the drug's rocky road from conception to clinic also validates the concept of rational drug design, an approach that will become more common as pharmaceutical companies mine human genome information. "It is extremely gratifying to have gone though the first laboratory determinations, to clinical

Although the research has only just begun at the newly established In vivo Cellular and Molecular Imaging Centers, or ICMICs, the researchers have jumped in and are covering many cancer research bases. Here are basic descriptions of activities under way at each of the centers. Massachusetts General Hospital/ Harvard Medical School At Massachusetts General Hospital/Harvard Medical School, virtually all imaging modalities are being put to the test, including optical near infrared fluorescence im

Although most of the studies now occurring in the In Vivo Cellular and Molecular Imaging Centers (ICMICs) are focused on basic animal research, investigators aren't wasting any time in moving the power of in vivo molecular imaging to human patients.

With the potential for catching serious metabolic disorders before symptoms appear, medical laboratories in the United States are increasingly screening newborns using tandem mass spectrometry (MS/MS) technology. A recent Morbidity and Mortality Weekly Report by the Centers for Disease Control and Prevention (CDC) shows about 500,000 newborns underwent such screening last year, up from 60,000 in 1996. This report, "Using Tandem Mass Spectrometry for Metabolic Disease Screening Among Newborns" (w

The $4.18 billion National Cancer Institute budget request submitted by the Bush administration to Congress in April for fiscal year 2002 amounts to an 11.7 percent boost of $439 million over the current year's appropriation. The package, however, falls $850 million short of the amount NCI sought in its own "bypass budget" proposal. NCI requested $5.03 billion, a whopping 34 percent boost of $1.27 billion. The bypass budget is so-called because, under the National Cancer Act of 1971, NCI's bud

can quickly become resistant to linezolid during extended treatment.

Now that the dust has settled after publication of the human genome sequence, Sydney Brenner assesses the first draft.

The commercial fishing and conservationist communities have clashed many times over how to protect fishery resources and conserve marine ecosystems while also supporting the economies dependent on the oceans. However, a new twist in the argument is the louder call from both sides for better scientific support for fishery management decisions. Fisheries management approaches often focus on single species protection by limiting the number of days fishermen can work, the types of fishing gear use

In southeastern Minnesota, the residents of little Winona are being besieged by messages from the future. On the radio and in newspapers, on billboards and handouts, the town's approximately 27,000 residents are being exhorted to join a pilot program that will put their individual health management information online. Going well beyond mere E-mail communication between physician and patient, the Winona Health Online1 project foreshadows a not-too-distant time when many Americans will have person

Scientists and publishers generally agree that the Internet is sparking a science publishing revolution.1 They have yet to agree, however, on how to cultivate that revolution without alienating one another. The latest effort to push the online publishing envelope has a sizable group of scientists threatening to boycott journals whose content is not freely available in a public database six months after publication. This call for a "public library of science" (PLOS) has already caused quite a sti

A single all-embracing effort to characterize the human proteome is an unlikely prospect (D. Steinberg, "Is a Human Proteome Project Next?" The Scientist, 15[7]:1, April 2, 2001). Nevertheless, smaller-scale--though still massive--proteomics projects keep springing up. On April 4, Myriad Genetics Inc. (MGI), Hitachi Ltd., and Oracle Corp. announced a $185 million, three-year collaboration to identify all protein-protein interactions and biochemical pathways in the human body. Myriad Proteomics I