Adapting to Arsenic

Andean communities may have evolved the ability to metabolize arsenic, a trait that could be the first documented example of a toxic substance acting as an agent of natural selection in humans.

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TOXIC SELECTION: Arsenic exposure can be deadly, but high in the Andes, drinking water laced with the chemical may have driven genetic adaptation in local populations.© ISTOCK.COM/ANDREASKERMANN

In parts of Argentina, people have been drinking poison—arsenic, to be specific—for thousands of years. The river running through the Andean village of San Antonio de los Cobres (SAC) has arsenic levels up to 80 times the safe limit established by the World Health Organization (WHO); it seeps into the groundwater from volcanic bedrock. Arsenic levels in the region’s tap water were as high as 20 times the WHO’s limit before 2012, when a filtration system was installed. The villagers are descended from indigenous Atacameño people who have lived and drunk the water in northern Argentina for as long as 11,000 years. Since 1994, Swedish biologist Karin Broberg, of Stockholm’s Karolinska Institute, and colleagues at Uppsala and Lund Universities have been trying to figure out ...

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