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Humans, unlike some lucky members of the animal kingdom, have a very limited ability to regrow damaged or missing body parts. But a study published yesterday (October 9) in Science Advances finds that we can generate new proteins in joint cartilage, and this ability is more pronounced in joints farther from the center of the body, such as the ankles, than in those nearer in, such as the hips. The mechanism for this ability resembles that used by animals such as salamanders and axolotls to regrow lost limbs.
“We believe that an understanding of this ‘salamander-like’ regenerative capacity in humans, and the critically missing components of this regulatory circuit, could provide the foundation for new approaches to repair joint tissues and possibly whole human limbs,” says coauthor Virginia Kraus, who researches osteoarthritis at Duke University School of Medicine, in a university press release.
Kraus and her ...
