Through a series of sustained collaborations, Joshua Sanes has deciphered the molecular synergy that guides synapse formation.

Philippa “Pippa” Marrack has made some unanticipated discoveries about how the immune system functions in health and disease.

Dissatisfied with the uncertainty of crystallography, Ned Seeman invented a new way of assembling the molecules that encompass the logic of life.

Studying the earliest events in visual development, Carla Shatz has learned the importance of looking at one’s data with open eyes—and an open mind.

Ron Kaback didn’t believe that electrochemical gradients could power the transport of sugars and amino acids across cell membranes—until he proved that they do.

By Karen Hopkin Making the Gradient Ron Kaback didn’t believe that electrochemical gradients could power the transport of sugars and amino acids across cell membranes—until he proved that they do. H. RONALD KABACK Professor of Physiology University of California, Los Angeles F1000 Faculty Member: Neuronal Signaling Mechanisms Photo © 2011 Jim Cornfield Ron Kaback got hooked on membrane transport as a medical student at the Albert Einstei

Joy Ward is reaping the rewards of her studies on how plants handle global climate change—gathering academic accolades and presidential embraces along the way.

By Karen Hopkin Harvesting Ideas Joy Ward is reaping the rewards of her studies on how plants handle global climate change—gathering academic accolades and presidential embraces along the way. JOY WARD Associate Professor of Plant Physiological Ecology and Global Change University of Kansas F1000 Faculty Member, Physiological Ecology Jason Dailey As a teen, Joy Ward worked as a tour guide at Indian Caverns, Pennsylvania’s largest limestone

Rudolf Jaenisch enjoys climbing mountains, rafting rapids, and unraveling the secrets of pluripotency—knowledge that could someday lead to personalized regenerative medicine.

By Karen Hopkin Ready, Reset, Go Rudolf Jaenisch enjoys climbing mountains, rafting rapids, and unraveling the secrets of pluripotency—knowledge that could someday lead to personalized regenerative medicine. RUDOLF JAENISCH Professor of Biology, MIT Member, Whitehead Institute F1000 Head of Faculty, Genomics & Genetics Porter Gifford It was a misbehaving virus that drew Rudolf Jaenisch to epigenetics. As a postdoc in Arnold Levine’s

Lewis Cantley has made a career of turning chemical contaminants into groundbreaking discoveries—including novel lipids, potent inhibitors, and kinases involved in cancer.

By Karen Hopkin Impure Genius Lewis Cantley has made a career of turning chemical contaminants into groundbreaking discoveries—including novel lipids, potent inhibitors, and kinases involved in cancer. LEWIS C. CANTLEY Professor of Systems Biology, Harvard Medical School Chief, Division of Signal Transduction, Director of Cancer Research Beth Israel Deaconess Medical Center F1000 Section Head: Cell Signaling Porter Gifford I didn’t set out to