Blind Patient Recovers Partial Vision with Optogenetics

After receiving an intraocular injection of the gene for a light-sensitive protein, a 58-year-old man diagnosed with the neurodegenerative eye disease retinitis pigmentosa was able to locate objects on a table using engineered goggles.

Written byAlejandra Manjarrez, PhD
| 4 min read
a drawing of black goggles receiving a beam of light than is then transmitted to an eyeball. from the retina there is a zoom-in of blue and purple cells and purple viruses

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Since its early days in the mid-2000s, optogenetics, with its potential to activate neurons with light, emerged as a promising technique for restoring vision in blind patients. In recent years, at least two companies have announced the start of clinical trials to test optogenetics-based therapies in humans, and one of them recently announced that patients who were blind or nearly blind from retinitis pigmentosa could detect light and motion following treatment.

Today (May 24), a case study led by José-Alain Sahel of the University of Pittsburgh and Botond Roska of the University of Basel published in Nature Medicine provides the first detailed evidence in a peer-reviewed study of a person’s partial functional recovery of vision after optogenetic treatment.

“I think we optogeneticists were all extremely keen to see something like this, the first publication on actually [a] human being [gaining] some sight by optogenetic treatment,” says Sonja Kleinlogel of the ...

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  • alejandra manjarrez

    Alejandra Manjarrez is a freelance science journalist who contributes to The Scientist. She has a PhD in systems biology from ETH Zurich and a master’s in molecular biology from Utrecht University. After years studying bacteria in a lab, she now spends most of her days reading, writing, and hunting science stories, either while traveling or visiting random libraries around the world. Her work has also appeared in Hakai, The Atlantic, and Lab Times.

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