Building Nanoscale Structures with DNA

The versatility of geometric shapes made from the nucleic acid are proving useful in a wide variety of fields from molecular computation to biology to medicine.

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ERIK BENSON & BJORN HOGBERG. ATTRIBUTION 4.0 INTERNATIONAL (CC BY 4.0)

DNA—the biological information-storage unit and the mechanism by which traits are passed on from generation to generation—is more than just an essential molecule of life. In the chemical sense, the nucleic acid has properties that make it useful for nonbiological applications. Researchers are now using DNA to store massive amounts of data, for example, including books and images, a Shakespearean sonnet, and even a computer operating system, with data encoded in the molecule’s nucleotide sequences. At an even more fundamental level, DNA is a critical building block of nanoscale shapes and structures. Researchers have created myriad nanoscale objects and devices using the nucleic acid, with applications in biosensing, drug delivery, biomolecular analysis, and molecular computation, to name but a few. DNA provides a highly specific ...

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  • Arun Richard Chandrasekaran

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July/August 2017

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