mouse retina

Heteractis magnifica

fruit-fly brain

developing brain

neural networks

tails

November Issue Cover

Intelligent Science

<em>The Scientist</em>

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Developmental Biology

Caught on Camera

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Science Snapshot

Image of Julie Huber holding up vials of different deep-sea microbe cultures.

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Fantastic Microbes and Where to Find Them

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A grayscale image of several small, round zebrafish embryos. 

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On the left, several white sperm face towards a pink ball representing an egg, which is held in a woman’s hand.

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How Cryptic Female Choice Shapes the Evolution of Species

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An illustration that shows the different measures taken to save US cotton from pink bollworm pest.

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How America&rsquo;s Cotton Farmers Eradicated the Pink Bollworm

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An extremophile hunt is underway to leverage their resilience tactics, from medicine to space exploration.

Memory-enhancing neural networks may also drive involuntary musical loops in the brain. 

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Illustration of the profile of a human head, with the top of the head opened up to show a pink brain. A worm is standing up inside of the brain, with a string of musical notes coming from it. 

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What Causes an Earworm? 

Life Sciences

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New fluidics and clog detection systems further simplify operation and reduce instrument downtime

Introducing the iQue 5 HTS Platform: Empowering Scientists &nbsp;with Unbeatable Speed and Flexibility for High Throughput Screening by Cytometry

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Researchers aim to discover dominant subtypes of plasmablasts initiating from the MMR vaccine in order to develop neutralizing antibody candidate therapies

Vanderbilt Selects Parse Biosciences GigaLab to Generate Atlas of Early Neutralizing Antibodies to Measles, Mumps, and Rubella

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Study identifies new metrics to enhance scRNA-seq based virtual cell modelling

Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery

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Redefining Lab Vacuum with Efficiency, Flexibility, and Sustainability

BRANDTECH Scientific Launches New Website for VACUU&middot;LAN&reg; Lab Vacuum Systems

Explore synthetic DNA’s many applications in cancer research

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Twist Bioscience

Modern DNA synthesis platforms empower researchers to explore the molecular world, from next-generation sequencing to cell and gene therapy development.

Weaving the Fabric of Cancer Research with Synthetic DNA

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Cytiva

An improved chromatography membrane elution method helps scientists achieve higher yields of pure plasmid DNA.

Enhancing Elution of Plasmid DNA

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By fine-tuning polishing conditions, scientists attain high titers of infectious lentiviral particles during purification.

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Explore new strategies for improving plasmid DNA manufacturing workflows.

Discover a scalable and flexible GMP-compliant workflow for producing plasmid DNA.

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SNAPSHOT: A map of the entire fruit-fly brain details the positions and connections of roughly 100,000 neurons. Posted: July 20, 2018 Z. Zheng et al., Cell, doi:10.1016/j.cell.2018.06.019, 2018. Visualization by Philipp Schlegel (Drosophila connectomics group, Cambridge HIDE AND SEEK: Scientists reported this year that the subplate, a predominant layer (bright blue region above the orange cells) of the developing brain, does not disappear in adults, as previously thought. Posted: June 26, 2018 M.Z. Ozair et al., Cell Stem Cell, doi:10.1016/j.stem.2018.05.024, 2018. Courtesy of the Laboratory of Stem Cell Biology and Molecular Embryology at the Rockefeller University THE FIVE PERCENT: A recently published map of neural networks in the striatum (green dots in center) of the mouse brain reveals previously underappreciated connections. Posted: May 7, 2018 J.R. Klug et al., eLife, 10.7554/eLife.35657, 2018. Courtesy of the Salk Institute OCEAN WONDER: Synthetic molecules similar to those produced by sea anemones, such as this Heteractis magnifica, are neuroprotective in a mouse cell model of Alzheimer’s disease. Posted: September 4, 2018 A.N. Kvetkina et al., Russ J Bioorg Chem+, doi:10.1134/S106816201804012X, 2018. Courtesy of Neville Wootton THROW THE SWITCH: A computer model of the mouse retina can predict the consequences of altering the function of neurons, such as these horizontal cells. Posted: June 27, 2018 A. Drinnernberg et al., Neuron, doi:10.1016/j.neuron.2018.06.001, 2018. REVIVAL: The varying regenerative properties of amphibian, reptile, and mammal tails result from differences in neural stem cells found in the animals' spinal cords, according to a recent study. Posted: August 17, 2018 A.X. Sun et al., PNAS, doi:10.1073/pnas.1803780115, 2018. Courtesy of Thomas P. Lozito

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