The lungs of patients with cystic fibrosis harbor a different microbial makeup, including less diversity of species, than the lungs of healthy individuals, according to a study published Wednesday (September 26) in Science Translational Medicine.
Although the disease is caused by a genetic mutation, bacterial infections of the lungs cause many of the complications experienced by these patients, and can even lead to death. The new study shows that decreased microbial diversity plays a role in these complications. “Diminished microbial diversity is associated with severity of pulmonary inflammation within our adult CF cohort,” the Stanford University-based authors write in their report.
The team compared the 16S ribosomal RNA sequences—a segment of genetic information that is used to determine the phylogeny of a species—from sputum samples taken from 16 normal study participants and nine cystic fibrosis patients. Healthy participants had more bacteria from the phyla Baceriodetes and Fusobacteria, while cystic fibrosis ...
