DNA Could Hold Clues to Varying Severity of COVID-19

Hundreds of scientists around the globe are launching studies in search of genes that could explain why some people fall victim to coronavirus infection while others escape relatively unscathed.

marla broadfoot
| 4 min read
coronavirus covid-19 host genetics genome gwas samples genes susceptibility severe cases sars-cov-2

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Among the many mysteries that remain about COVID-19, the disease caused by the new coronavirus, is why it hits some people harder than others. Millions of people have been infected, but many never get sick. Those who do can experience an ever-expanding array of symptoms, including loss of smell or taste, pink eye, digestive issues, fever, cough, and difficulty breathing. Although the elderly, those with pre-existing conditions such as heart disease, and men are most likely to suffer severe complications, hundreds of young and previously healthy people have died from the disease in the US alone.

In recent weeks, researchers have begun asking whether genetics could influence the severity of symptoms.

So far, they know “basically nothing,” Wendy Chung, a clinical geneticist and physician at Columbia University, tells The Scientist. She is one of hundreds of scientists launching studies to interrogate the human genome for answers. ...

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Meet the Author

  • marla broadfoot

    Marla Broadfoot

    Marla Broadfoot is a freelance science journalist and contributing editor at American Scientist. Her work has appeared in ScienceSTATScientific American, Discover, Nature News, and Science News, among others. She has a PhD in genetics and molecular biology from the University of North Carolina at Chapel Hill and was a postdoc at the National Human Genome Research Institute in Bethesda, MD. She is based in Wendell, NC.

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