An inexpensive, over-the-counter pain reliever can kill the bacteria that cause tuberculosis (TB)—even the drug-resistant varieties—according to a new study published online in the Proceedings of the National Academy of Science this week (September 10), yet it’s not a promising candidate for drug trials.
Researchers at the Weill Cornell Medical College designed a screen to find drugs that target dormant TB bacteria—triggered by certain lung conditions, dormancy is a key strategy Mycobacterium tuberculosis uses to evade drugs and cause lethal infections in nearly 1.5 billion people per year. The researchers found that the anti-inflammatory drug oxyphenbutazone, developed to treat arthritis in the 1970s, is activated in lung conditions that induce dormancy, and can kill dormant, active, and even resistant bacteria.
But the researchers are skeptical the drug will ever be given to a TB patient. “It is difficult today to launch clinical studies on a medication that is so outdated ...
