Drug for Still’s Disease Shows Promise in Phase 2 Trial

Patients with the rare autoimmune condition, highlighted in the Oscar-nominated film The Big Sick, currently have limited treatment options.

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Zoe Kazan as Emily and Kumail Nanjiani as himself in The Big SickFLICKR, BAGOGAMESReaders take note: movie spoilers ahead

In the movie The Big Sick, based on real events that happened to its two Academy Award-nominated scriptwriters, the character Emily falls gravely ill and is put into a medically induced coma as doctors race to treat what they believe is an antibiotic-resistant infection. When they finally diagnose her with a rare autoimmune condition called adult-onset Still’s disease, treating the symptoms seems trivial, and Emily is soon out of the coma and back on her feet.

It turns out that treating Still’s in real life isn’t always so simple. Some patients’ symptoms aren’t immediately resolved by first-line treatments, and many experience periodic flare-ups after the initial bout of symptoms. But a Swiss trial reported last month (February 22) in the Annals of the Rheumatic Diseases ...

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Meet the Author

  • Shawna Williams

    Shawna was an editor at The Scientist from 2017 through 2022. She holds a bachelor's degree in biochemistry from Colorado College and a graduate certificate and science communication from the University of California, Santa Cruz.
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