Genomes Point the Way

Sequence analysis of Egyptian, Ethiopian, and non-African peoples indicates a likely route taken by modern humans migrating out of Africa.

ruth williams
| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

WIKIMEDIA, BAMSEModern human populations expanded out of Africa some 50,000 to 100,000 years ago, but whether the exodus primarily followed a route through North Africa and Egypt, or across the Bab el Mandeb strait to Yemen has been a matter of debate. Now, through an analysis based on sequence comparisons between modern Egyptians, Ethiopians, Europeans, and Asians, researchers from the University of Cambridge and their colleagues suggest that the Northern route is most likely. The results of the study are published today (May 28) in the American Journal of Human Genetics.

“This paper goes much further beyond any of the other prior genetic studies in really trying to address this question [of route],” said human evolutionary geneticist Brenna Henn of Stony Brook University in New York who was not involved in the work. “There are many caveats associated with this type of work but it’s impressive that they tried to very explicitly test this hypothesis . . . I give them kudos for that.”

Europeans and Asians (Eurasians) are, for the most part, fairly genetically homogeneous and thus most likely descended from a single group of modern humans who left Africa, said Luca Pagani of Cambridge who led the study. However, whether these early migrants traveled up the Nile and out of Africa via Egypt (Northern ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • ruth williams

    Ruth Williams

    Ruth is a freelance journalist.
Share
May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

View this Issue
iStock

TaqMan Probe & Assays: Unveil What's Possible Together

Thermo Fisher Logo
Meet Aunty and Tackle Protein Stability Questions in Research and Development

Meet Aunty and Tackle Protein Stability Questions in Research and Development

Unchained Labs
Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

Thermo Fisher Logo

Products

The Scientist Placeholder Image

Biotium Launches New Phalloidin Conjugates with Extended F-actin Staining Stability for Greater Imaging Flexibility

Leica Microsystems Logo

Latest AI software simplifies image analysis and speeds up insights for scientists

BioSkryb Genomics Logo

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours

iStock

Agilent BioTek Cytation C10 Confocal Imaging Reader

agilent technologies logo