Hormones May Contribute to Asymmetrical Effects of Brain Injury

Researchers studying rats claim to have found a novel connection between damage on one side of the brain and problems with the posture or movement of limbs on the opposite side of the body.

Written byCatherine Offord
| 4 min read
Illustrated rat

Register for free to listen to this article
Listen with Speechify
0:00
4:00
Share

ABOVE: ADAPTED FROM GIL COSTA (CC BY 4.0) AND A PHOTOGRAPHIC REPRODUCTION OF DE SPORTLIEDEN BY KAZIMIR MALEVICH

Injury to one side of the brain can cause abnormalities in posture or movement on the opposite side of the body. These effects, which are sometimes seen in people who have suffered a stroke or head trauma, have typically been attributed to neural pathways that link the right side of the brain to spinal cord neurons controlling muscles on the left side of the body, and vice versa.

But in a new study on rats that had their spinal cords severed, researchers claim to have discovered another, parallel pathway that triggers opposite-side effects following brain injury and might instead operate via hormones circulating in the blood. The work was published last month (August 10) in eLife.

The findings are “interesting and surprising,” says S. Thomas Carmichael, a neurologist at the University of ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • After undergraduate research with spiders at the University of Oxford and graduate research with ants at Princeton University, Catherine left arthropods and academia to become a science journalist. She has worked in various guises at The Scientist since 2016. As Senior Editor, she wrote articles for the online and print publications, and edited the magazine’s Notebook, Careers, and Bio Business sections. She reports on subjects ranging from cellular and molecular biology to research misconduct and science policy. Find more of her work at her website.

    View Full Profile
Share
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies