How Caffeine Fights Cancer

Caffeinated drinks may help prevent skin cancer by inhibiting a DNA repair pathway, thus killing potentially precancerous cells.

Written byJef Akst

| 3 min read

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WIKIMEDIA COMMONS, JULIUS SCHORZMAN

Epidemiological studies have shown that drinking caffeinated beverages reduces one’s chances of developing some types of cancer, including UV-associated skin cancer. Now, researchers propose a possible mechanism for this observation—the inhibition of a DNA repair pathway that sensitizes cells to death after sun exposure.

The results, published today (August 15) in the Proceedings of the National Academy of Sciences, lend support to the idea that caffeine could be added to sunblock to increase its protective effects.

“At the cellular level, they’re showing that caffeine…is working in this way of inducing an apoptotic mechanism,” said cancer epidemiologist Joanne Kotsopoulos of the University of Toronto, who was not involved in the research. “It’s biologically plausible, and it has good implications” for potential skin cancer prevention strategies.

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Meet the Author

Jef Akst
Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.
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