When Xenopus frog eggs are experimentally ruptured, their cytoplasm rearranges itself to form compartments similar to cells, according to a study published October 31 in Science. The researchers, led by James Ferrell, a systems biologist at Stanford University, found that the reorganization occurred with or without the addition of sperm nuclei, suggesting that the mechanism is inherent in the eggs.
“If you take the cytoplasm of the frog egg—note that the cytoplasm has been homogenized, so whatever spatial structure that was there has been completely disrupted—and just let it sit at room temperature, it will reorganize itself and form small cell-like units. That’s pretty amazing,” says Xianrui Cheng, a postdoc in Ferrell’s lab and the first author of the paper, in a news release.
The team found that the energy source adenosine triphosphate, structural elements such as microtubules, and the motor protein dynein were required to form the structures, while ...
