RNA-binding proteins dNab2 (purple) and dFMRP (green), colocalize in a Drosophila neuron (neuronal membrane in red).KEN MOBERG Scientists demonstrate that the protein FMRP, encoded by the disease-initiating gene in Fragile X syndrome, doesn’t work alone to alter gene expression in fruit fly neurons. Instead, it partners with the RNA-binding protein dNab2.
See R.S. Bienkowski et al., “The conserved, disease-associated RNA binding protein dnab2 interacts with the fragile x protein ortholog in drosophila neurons,” Cell Reports, 20:1327-84, 2017.
