New Tissue Clearing Methods Offer a Window into the Brain
New Tissue Clearing Methods Offer a Window into the Brain
Researchers are developing a variety of approaches for clearing neural tissue to get a better view of the brain’s circuitry.
New Tissue Clearing Methods Offer a Window into the Brain
New Tissue Clearing Methods Offer a Window into the Brain

Researchers are developing a variety of approaches for clearing neural tissue to get a better view of the brain’s circuitry.

Researchers are developing a variety of approaches for clearing neural tissue to get a better view of the brain’s circuitry.

Lab Tools
Genetics Models Move Beyond <em>Drosophila</em> and the Humble Lab Mouse
Genetics Models Move Beyond Drosophila and the Humble Lab Mouse
Amber Dance | Sep 1, 2019
Organisms with unusual genomes are helping scientists investigate gene regulation, evolution, and development.
Strategies for Smuggling Gene Therapies Past the Immune System
Strategies for Smuggling Gene Therapies Past the Immune System
Monique Brouillette | Jul 15, 2019
Researchers are devising ways to prevent viral vectors carrying gene therapies from triggering an immune response.
Drug Discovery Techniques Open the Door to RNA-targeted Drugs
Drug Discovery Techniques Open the Door to RNA-targeted Drugs
Amber Dance | Jun 1, 2019
New ways to search for druggable RNAs and matching small molecules
Using Machine Learning to Battle Antibiotic Resistance
Using Machine Learning to Battle Antibiotic Resistance
Amber Dance | May 1, 2019
Researchers are using artificial intelligence to identify known and novel resistance genes.
Contending with Resistance in Cancer Immunotherapy
Contending with Resistance in Cancer Immunotherapy
Marissa Fessenden | Apr 1, 2019
Researchers describe ways to study how cancer cells evade therapies that harness the immune system.
The Challenge of Using CRISPR to Knock In Genes
The Challenge of Using CRISPR to Knock In Genes
Anna Nowogrodzki | Mar 1, 2019
Researchers are developing an array of techniques for accurately and efficiently inserting genes into DNA.
Mapping the Cellular Social Network of Proteins
Mapping the Cellular Social Network of Proteins
Melissae Fellet | Feb 1, 2019
Three techniques capture data on numerous protein interactions in plants, mice, and human cells.
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Ashley Yeager | Jan 1, 2019
Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.
Imaging Chromatin to Deduce Function from Form
Imaging Chromatin to Deduce Function from Form
Marissa Fessenden | Dec 1, 2018
Researchers describe their tools for probing how the physical shape of the genome affects genes’ function.
Using Temperature-Sensitive Channels to Study Neural Circuitry
Using Temperature-Sensitive Channels to Study Neural Circuitry
Devika G. Bansal | Nov 1, 2018
Meet the researchers building a thermogenetic toolbox.
Integrating Multiple -Omics in Individual Cells
Integrating Multiple -Omics in Individual Cells
Sandeep Ravindran | Oct 1, 2018
New techniques combine DNA, RNA, and protein information from single cells.
Speeding Up Stem Cell Growth
Speeding Up Stem Cell Growth
Amber Dance | Sep 1, 2018
Scientists fiddle with formulas to boost the growth of their stem cell cultures.
How to Track Metabolites in Tissues Using NMR
How to Track Metabolites in Tissues Using NMR
Katherine Bourzac | Aug 1, 2018
Whether it’s aligning software or prepping samples, researchers share their tips for studying the metabolome with this underused approach.
How to Calculate Mutation Rate for Evolutionary Biology
How to Calculate Mutation Rate for Evolutionary Biology
Amber Dance | Jul 1, 2018
Four ways to study mutation rate, a crucial statistic in studies of evolution
Using Mimics to Get Around Antibodies’  Limitations
Using Mimics to Get Around Antibodies’ Limitations
Devika G. Bansal | Jun 1, 2018
Synthetic and natural alternatives to traditional antibodies offer more control, specificity, and reproducibility. 
Computer Programs Sift Through Spikes in Nerve Cells’ Activity
Computer Programs Sift Through Spikes in Nerve Cells’ Activity
Ashley Yeager | May 1, 2018
Software that can separate signals from noise brings neuroscientists a step closer to understanding neurons’ patterns of communication.
Of Mice and Metastasis
Of Mice and Metastasis
Amanda B. Keener | Apr 1, 2018
Tools for studying how cancer spreads
New Methods to Detect CRISPR Off-Target Mutations
New Methods to Detect CRISPR Off-Target Mutations
Sandeep Ravindran | Mar 1, 2018
Researchers have developed a variety of techniques to detect when CRISPR misses the mark.
Virtual Reality May Revolutionize Brain Science
Virtual Reality May Revolutionize Brain Science
Ashley Yeager | Feb 1, 2018
New technology could open doors for researchers studying animals’ most complex organ.