Features

Freezing Time
Vern L. Schramm | May 1, 2012
Targeting the briefest moment in chemistry may lead to an exceptionally strong new class of drugs.
Data Diving
Kerry Grens | May 1, 2012
What lies untapped beneath the surface of published clinical trial analyses could rock the world of independent review.
Telomeres in Disease
Rodrigo Calado and Neal Young | May 1, 2012
Telomeres have been linked to numerous diseases over the years, but how exactly short telomeres cause diseases and how medicine can prevent telomere erosion are still up for debate.

Editorial

Speaking of Science

Speaking of Science
Speaking of Science
May 2012's selection of notable quotes

Notebook

The Sound of Color
The Sound of Color
A completely colorblind musician and painter perceives the world in a new way with help from technology.
From Squeaks to Song
From Squeaks to Song
From Squeaks to Song
House mice sing melodies out of the range of human hearing, and the crooning is impacting research from evolutionary biology to neuroscience.
Mighty Moth Man
Mighty Moth Man
An evolutionary biologist’s posthumous publication restores the peppered moth to its iconic status as a textbook example of evolution.
It’s Raining Mice
It’s Raining Mice
It’s Raining Mice
A new brown tree snake control strategy takes to the skies as scientists scatter toxic rodents over Guam’s forest canopy.

Critic at Large

Cooking Up Creative Solutions
Cooking Up Creative Solutions
More collaborators and more data are the key ingredients.

Modus Operandi

Bubble Vision
Bubble Vision
Turning a liability into an asset, cryo-electron microscopists exploit an artifact to probe protein structure.

The Literature

The Sugar Lnc
The Sugar Lnc
Genes that react to cellular sugar content are regulated by a long non-coding RNA via an unexpected mechanism
Ginormous Genome
Ginormous Genome
Researchers find organisms with huge genomes with high mutation rates, overturning a common expectation in evolutionary biology.
Tumor Turnabout
Tumor Turnabout
A cytokine involved in suppressing the immune system may actually activate it to kill cancer cells.

Profile

Burgers and Flies
Burgers and Flies
Inspired by Darwin, Mohamed Noor has uncovered the molecular dance by which a single species becomes two.

Scientist to Watch

Robert Blelloch: Teacher, Doctor, Scientist
Robert Blelloch: Teacher, Doctor, Scientist
Associate Professor, Department of Urology, University of California, San Francisco. Age: 45

Lab Tools

SPRead Your Antibody Capabilities
SPRead Your Antibody Capabilities
Using surface plasmon resonance to improve antibody detection and characterization: four case studies
Pure Pursuits
Pure Pursuits
Techniques for simpler, cheaper, and better antibody purification

Bio Business

Treating Fat with Fat
Treating Fat with Fat
Is brown fat ready for therapeutic prime time?

Reading Frames

Dopamine: Duality of Desire
Dopamine: Duality of Desire
Being an ex-drug-addict turned neuroscientist brings a unique insight into the physiological and phenomenological realities of addiction.

Foundations

Boyle’s Monsters, 1665
Boyle’s Monsters, 1665
From accounts of deformed animals to scratch-and-sniff technology, Robert Boyle's early contributions to the Royal Society of London were prolific and wide ranging.

Contributors

Contributors
Contributors
Meet some of the people featured in the April 2012 issue of The Scientist.

Infographics

Telomere Basics
Telomere Basics
Telomere Basics
Telomeres are repetitive, noncoding sequences that cap the ends of linear chromosomes. They consist of hexameric nucleotide sequences (TTAGGG in humans) repeated hundreds to thousands of times. 
Designing Transition-State Inhibitors
Designing Transition-State Inhibitors
Designing Transition-State Inhibitors
A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. 

Capsule Reviews

Capsule Reviews
Capsule Reviews
Masters of the Planet, Learning from the Octopus, Darwin’s Devices, and Psychology’s Ghosts

Slideshows

Spot the Moth
Spot the Moth
It’s a well-known story: The peppered moth’s ancestral typica phenotype is white with dark speckles.