May 2018

Rare Diseases

The realities of studying uncommon conditions

Features

Exome Sequencing Helps Crack Rare Disease Diagnosis

How Orphan Drugs Became a Highly Profitable Industry

Families of Children with Rare Diseases Fuel Gene Therapy Research

A Devastating Diagnosis, a Viral Video, and a Clinical Trial

The Philadelphia Family Helping to Drive Research on MLD

Slow March Toward a Canavan Cure

Contributors

Contributors

Editorial

Bullets and Ballots

Speaking of Science

Ten-Minute Sabbatical

Freeze Frame

Caught on Camera

Notebook

Pinpointing the Origin of Marbled Crayfish Clones

Understanding What Makes a Successful Crowdfunding Campaign

Researchers Turn to Implantable Robots to Regenerate Tissue

Colorblindness Study Reveals Unexpected Way to Make Blood Vessels

Modus Operandi

Mitochondrial Isolation System

The Literature

Certain Glial Cells Appear to Help Prevent Muscle Fatigue

Big Data in 3 Dimensions

Copper Connections

Profiles

Rare Disease Geneticist: A Profile of Uta Francke

Scientist to Watch

Valerie Arboleda Uses Big Data to Unravel the Biology of a Rare Disease

Lab Tools

Computer Programs Sift Through Spikes in Nerve Cells’ Activity

Careers

Scientists Are Opting for Remote Postdoc Positions

Reading Frames

Rare to the Rescue

Foundations

Among the Amish, c. 1960s

May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

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Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

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Characterizing Immune Memory to COVID-19 Vaccination

Characterizing Immune Memory to COVID-19 Vaccination

10X Genomics
Optimize PCR assays with true linear temperature gradients

Applied Biosystems™ VeriFlex™ System: True Temperature Control for PCR Protocols

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Products

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Biotium Launches New Phalloidin Conjugates with Extended F-actin Staining Stability for Greater Imaging Flexibility

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Latest AI software simplifies image analysis and speeds up insights for scientists

BioSkryb Genomics Logo

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours

iStock

Agilent BioTek Cytation C10 Confocal Imaging Reader

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