Features

What Causes Alzheimer’s?
W. Sue T. Griffin | Sep 1, 2011
Researchers and pharma companies have tried to attack this disease by reducing amyloid plaques, but inflammation may be the real culprit.
Secrets of Aging
Carol Barnes | Sep 1, 2011
What does a normally aging brain look like? Are diseases of aging such as Alzheimer’s inevitable?
The 2011 Labby Multimedia Awards
Jessica P. Johnson | Sep 1, 2011
Introducing the winners of our second annual "Labbies" awards
Showcase Your Science
Jessica P. Johnson | Sep 1, 2011
Tips for creating a science video or website.

Profile

Beyond Expectation
Beyond Expectation
Philippa “Pippa” Marrack has made some unanticipated discoveries about how the immune system functions in health and disease.

Foundations

Animal Electricity, circa 1781
Animal Electricity, circa 1781
How an Italian scientist doing Frankenstein-like experiments on dead frogs discovered that the body is powered by electrical impulses.

Slideshows

<em>Art + Science Now</em>
Art + Science Now
Art + Science Now
The book that serves as bio art's encyclopedia.

Infographics

The Seat of Memory
The Seat of Memory
The Seat of Memory
Early on, researchers had learned that the hippocampus was the structure in the brain where long-term memories were created and stored, but it was not known whether the different cell types within this structure might be more or less susceptible to the aging process.
Lost in Space
Lost in Space
Lost in Space
Looking for a more realistic way to study memory, we turned to place cells­­—­a network of cells that record a rat’s memory of an environment. 
Molecular Learning
Molecular Learning
Molecular Learning
Long-term potentiation (LTP), discovered in the 1970s, was later shown to be the molecular basis of memory. 
The Cytokine Cycle
The Cytokine Cycle
The Cytokine Cycle
The initiating cause of Alzheimer’s disease is still unknown. However, from our studies it’s clear that many types of neuronal damage—­­from traumatic brain injury, to epilepsy, infection, or genetic predisposition—­can activate brain immune cells—microglia and astrocytes-- promoting them to produce IL-1 and S100 inflammatory cytokines.

Careers

Poster Perfect
Poster Perfect
Poster Perfect
How to drive home your science with a visually pleasing poster

Notebook

Blood Simple
Blood Simple
A veterinary vaccine spawned products that could clean the HIV virus from blood supplies.
To Pee or Not to Pee
To Pee or Not to Pee
Have researchers found the seat of urination control in a primitive brain region?
Octophilosophy
Octophilosophy
When it comes to studying cephalopod brains and behavior, it helps to have a philosopher around.
Adapting to Climate Change
Adapting to Climate Change
Indigenous populations are especially vulnerable to the effects of global climate change. A new research project aims to help them adapt.

The Literature

Amoebae Get Organized
Amoebae Get Organized
Editor’s Choice in Developmental Biology
Ribosomes in Control
Ribosomes in Control
Editor’s Choice in Cell Biology
Piggyback Pathogen
Piggyback Pathogen
Editor’s Choice in Immunology

Lab Tools

Speak, RNA
Speak, RNA
A trip through the transcriptome

Speaking of Science

Speaking of Science
Speaking of Science
September 2011's selection of notable quotes

Critic at Large

Vive la Différence
Vive la Différence
Measuring how individual cells differ from each other will enhance the predictive power of biology.

Scientist to Watch

Corina Tarnita: The Ant Mathematician
Corina Tarnita: The Ant Mathematician
Junior Fellow, Harvard Society of Fellows, Harvard University. Age: 28

Thought Experiment

Puncturing the Myth
Puncturing the Myth
Purinergic signaling, not mystical energy, may explain how acupuncture works.

Capsule Reviews

Capsule Reviews
Capsule Reviews
Art + Science Now, Signs of Life, Perceptions of Promise, Green Light

Modus Operandi

Deep Tissue Treatment
Deep Tissue Treatment
A new, genetically encoded tag for electron microscopy may revolutionize studies of specific proteins in cells and tissues.

Reading Frames

What Price Kindness?
What Price Kindness?
Exposing the life and work of a visionary and troubled scientist opens a window onto the evolution of altruism.

Editorial

Hold That Thought
Hold That Thought
In the memory circuits of the aging brain and the signaling pathways of pain, science is trading mystery for mastery.

Contributors

Contributors
Contributors
Meet some of the people featured in the September 2011 issue of The Scientist.