Novel Type of Immune Cell Discovered in Type 1 Diabetes Patients

A rogue hybrid lymphocyte, bearing characteristics of both B and T cells, may play a role in driving autoimmunity in the disease, although the mechanism is far from clear.

Written byKatarina Zimmer
| 6 min read
x lymphocyte DE cell immune immunology t cell b cell type 1 diabetes

Register for free to listen to this article
Listen with Speechify
0:00
6:00
Share

ABOVE: Colorized scanning electron micrographs of B and T lymphocytes (left, right) shown with a fluorescent microscopy image of the newly discovered DE cell, also called the X cell to denote its crossover nature between B cells and T cells (center).
B AND T CELL IMAGES FROM THE NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; X CELL IMAGE FROM JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

According to textbooks, cells of the adaptive immune system must be either B cells or T cells—they can’t be both, or anything in between. But proving once again that nature is full of surprises, scientists have now discovered a novel type of lymphocyte in type 1 diabetes patients that combines characteristics of B cells and T cells. The researchers suggest that these hybrids could play an important role in the disease by encouraging the immune system to attack the body’s own insulin-producing cells, they report today ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • katya katarina zimmer

    After a year teaching an algorithm to differentiate between the echolocation calls of different bat species, Katarina decided she was simply too greedy to focus on one field of science and wanted to write about all of them. Following an internship with The Scientist in 2017, she’s been happily freelancing for a number of publications, covering everything from climate change to oncology. Katarina is a news correspondent for The Scientist and contributes occasional features to the magazine. Find her on Twitter @katarinazimmer and read her work on her website.

    View Full Profile
Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH