Resveratrol’s Low-Dose Anticancer Effect

The antioxidant found in red wine and some berries shows that small doses have more potent antitumor effects than large doses in a mouse model.

Written byBob Grant
| 2 min read

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WIKIMEDIA, LOURDES CARDENALSmall amounts of resveratrol, the chemical in red wine and some berries that is purported to have cancer-fighting properties, may be more effective at preventing tumor growth than larger doses, according to researchers studying cancer-prone mice. A team of scientists from the U.K. and the U.S. published its results in Science Translational Medicine on Wednesday (July 29).

“For the first time, we’re seeing that less resveratrol is more,” team leader Karen Brown of the University of Leicester said in a statement. “This study shows that low amounts may be better at preventing tumors than taking a high dose.”

Brown and her team studied mice that had been engineered to spontaneously develop bowel cancer. After feeding the animals a high fat diet with varying amounts of resveratrol, the researchers found that a dose that was equivalent to a human adult consuming a large glass of red wine was more effective at shrinking tumors than a dose 200 times higher. Tumors in mice administered low doses of resveratrol shrunk by 50 percent, while the high-resveratrol dose mice showed only a 25 percent reduction in ...

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  • From 2017 to 2022, Bob Grant was Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer. Before joining the team, he worked as a reporter at Audubon and earned a master’s degree in science journalism from New York University. In his previous life, he pursued a career in science, getting a bachelor’s degree in wildlife biology from Montana State University and a master’s degree in marine biology from the College of Charleston in South Carolina. Bob edited Reading Frames and other sections of the magazine.

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