A lethal form of Salmonella prevalent in sub-Saharan Africa may have evolved to take advantage of weaknesses in the immune system created by the emergence of HIV, according to a report in Nature Genetics released this week (September 30).
A relative of the Salmonella commonly linked to cases of food poisoning, this strain—known as invasive nontyphoidal Salmonella (iNTS)—is spread from person to person and kills up to half the adults it infects. But little is known about how it became so widespread throughout sub-Saharan Africa in the past 50 years.
So researchers at the Wellcome Trust Sanger Institute in Cambridge, UK, sequenced the genomes of 129 isolates of Salmonella typhimurium—the most common cause of the disease—collected from seven African countries between 1988 and 2010. Organizing them into family trees, they found two distinct lineages that emerged and spread in ways that overlapped the spread of HIV. And when compared to ...
