Artist’s rendition of bright blue microbes among intestinal lining
Study Links Depression with High Levels of an Amino Acid
Experiments in animals and observations in humans suggest that the amount of proline circulating in one’s plasma has a strong association with depression severity.
Study Links Depression with High Levels of an Amino Acid
Study Links Depression with High Levels of an Amino Acid

Experiments in animals and observations in humans suggest that the amount of proline circulating in one’s plasma has a strong association with depression severity.

Experiments in animals and observations in humans suggest that the amount of proline circulating in one’s plasma has a strong association with depression severity.

animal models
A white mouse huddles with some of her nine-day-old pups.
In Vivo Gene Therapy Cures Infertility in Mice
Dan Robitzski | May 2, 2022
Mice rendered infertile through ovary cell–targeting mutations gave birth to seemingly normal offspring through natural mating after a virus-based gene therapy was injected into their ovaries.
Image of brain cells showing pyramidal neurons in green, astrocytes in red, and microglia in blue
Replacing Microglia Treats Neurodegenerative Disease in Mice
Shawna Williams | Mar 17, 2022
Researchers find a way to wipe out the brain’s immune cell corps and send in new and improved versions.
Next-Level Organoids
Next-Level Organoids
The Scientist Creative Services Team
Researchers use organoid cultures in unique ways to study health and disease.
Thomas Lozito poses with Donald, one of his mourning geckos.
Thomas Lozito Is Figuring Out How Lizards Rebuild
Connor Lynch | Feb 14, 2022
The University of Southern California bioengineer studies how lizards regrow their tails, with the goal of one day inducing regeneration in humans.
grey and purple cancer cells under a microscope
Cell Diversity Could Spell Trouble for Animal Models of Cancer
David Adam | Nov 19, 2021
Tracking human cancers in mice shows some unexpected cell changes that could undermine translational research.  
Learn about hot topics in organoid research
Next-Level Organoids
The Scientist Creative Services Team
Researchers use organoid cultures in unique ways to study health and disease.
a leopard gecko with an unusually yellow body
“Lemon Frost” Leopard Geckos’ Cancers Similar to Human Melanomas
Christie Wilcox | Jun 24, 2021
The color morph’s bright yellow hue and its propensity for skin tumors both likely stem from a gene implicated in a dangerous form of human skin cancer, suggesting the animals could make an ideal model for studying the disease.
The Many Model Systems of COVID-19
Abby Olena | Nov 4, 2020
Researchers turn to familiar model animals, along with some fresh strategies, to develop countermeasures against SARS-CoV-2 and investigate the biology of infection.
Stem Cell Transplant Treats Parkinson’s Disease in Monkeys
Roni Dengler, PhD
Personalized stem cells improved motor symptoms and depression signs in monkeys modeling Parkinson’s disease, paving the way for trials in human patients.
Michelle Gray Tracks Huntington’s in Different Brain Cells
Amanda Heidt | Oct 1, 2020
The University of Alabama at Birmingham neuroscientist aims to determine which cells are most important in prompting the disease’s initiation and progression.
stroke, animal model, mouse model, blood, cytokine storm, immune system, immune response, MMP-9, neutrophil
Blood Replacement Rescues Mice from Stroke Damage
Amanda Heidt | Aug 31, 2020
When mice that had suffered a stroke were given blood from a healthy donor, they experienced less tissue and neurological damage.
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A New Model with Fully Functioning Blood Vessels Mimics Brain Cancer
Roni Dengler, PhD
A newly developed platform may one day replace cell culture and animal models to personalize cancer treatment.
Noel Rose, Immunology, Autoimmune Disease, John Hopkins University, University at Buffalo, Microbiology, Antigens
Noel Rose, Who Demonstrated Autoimmunity Exists, Dies at 92
Amanda Heidt | Aug 10, 2020
The Johns Hopkins University researcher bucked the prevailing idea that the body would not launch an immune response against its own tissues, and in doing so established an entirely new scientific discipline.
Image of the Day: Biomimetic Arteries
Amy Schleunes | Apr 6, 2020
A newly engineered synthetic blood vessel offers a novel platform for developing drugs that treat high blood pressure.
Gaining Biological Insights into Brain Development Using Single Cell Technologies
Gaining Biological Insights into Brain Development Using Single Cell Technologies
The Scientist Creative Services Team in collaboration with 10x Genomics
Richard Smith will discuss the importance of ionic flux in in utero neuronal development.
Cells’ Response to SARS-CoV-2 Different from Flu, RSV
Abby Olena | Mar 31, 2020
The host transcriptional signature elicited by the coronavirus appears to be less robust and lacks the induction of key antiviral genes.
Animal Facilities Make Tough Decisions as Pandemic Closes Labs
Abby Olena | Mar 27, 2020
Many researchers have stopped breeding mice, reduced the size of colonies, and established contingency plans in case animal care staff get sick.
The Epigenetic Origins of Allergy and Asthma
The Scientist Speaks Ep. 15 - The Epigenetic Origins of Allergy and Asthma
The Scientist Creative Services Team
Epigenetic marks acquired from environmental exposures throughout life influence human health and may even transcend generations.
US Primate Centers Work to Protect Animals from COVID-19
Ashley Yeager | Mar 19, 2020
Rhesus macaques can be infected with SARS-CoV-2, leading primate center scientists to try to prevent outbreaks in their colonies, especially as experiments on coronavirus start.