Mouse Model Shows How Parkinson’s Disease Begins in the Gut
Mouse Model Shows How Parkinson’s Disease Begins in the Gut
Johns Hopkins’s Ted Dawson discusses his lab’s demonstration that misfolded α-synuclein can move from the stomach to the brain and cause physical and cognitive symptoms.
Mouse Model Shows How Parkinson’s Disease Begins in the Gut
Mouse Model Shows How Parkinson’s Disease Begins in the Gut

Johns Hopkins’s Ted Dawson discusses his lab’s demonstration that misfolded α-synuclein can move from the stomach to the brain and cause physical and cognitive symptoms.

Johns Hopkins’s Ted Dawson discusses his lab’s demonstration that misfolded α-synuclein can move from the stomach to the brain and cause physical and cognitive symptoms.

animal models
Image of the Day: Seizure Proteins
Image of the Day: Seizure Proteins
Nicoletta Lanese | Aug 14, 2019
The sei ion channel in fruit flies keeps their neuronal excitability in check.
Wellcome Sanger Institute to Close Animal Facility
Wellcome Sanger Institute to Close Animal Facility
Chia-Yi Hou | Jun 10, 2019
The move reflects scientists using more cell lines and organoids in genetic research, although some experts disagree with the decision to scale back the use of animal models.
Opinion: AI Beats Animal Testing at Finding Toxic Chemicals
Opinion: AI Beats Animal Testing at Finding Toxic Chemicals
Thomas Hartung | May 1, 2019
Machine learning could be the key to reducing the use of animals in experiments.
Swiss Researchers Struggle to Get Animal Experiments Approved
Swiss Researchers Struggle to Get Animal Experiments Approved
Diana Kwon | Jan 8, 2019
Scientists say that increasingly rigorous licensing procedures have complicated research efforts—and in some cases, stopped experiments completely.
Lab Animal Use in the UK Dips Below 2010 Levels
Lab Animal Use in the UK Dips Below 2010 Levels
Katarina Zimmer | Jul 27, 2018
A report finds a decline in the number of experiments involving animals in 2017, noting a particular decrease in procedures on dogs and primates.
Want to Boost Reproducibility? Get Another Lab Involved
Want to Boost Reproducibility? Get Another Lab Involved
Jim Daley | Feb 22, 2018
Including as few as two labs in a study improved the odds of getting the true effect size by as much as 23 percentage points, according to a replication model.
“Retired” Mice Find New Life as Top Models for Autism
“Retired” Mice Find New Life as Top Models for Autism
Jessica Wright | Jan 29, 2018
After years of obscurity, strains of mice with mutations in particular genes are thrust to the fore of autism research.
Study Raises Questions About Patient-Derived Xenografts
Study Raises Questions About Patient-Derived Xenografts
Ashley P. Taylor | Oct 10, 2017
When transplanted into mice, tumor genomes evolve differently than they do in patients, study finds.
Image of the Day: Fish Avatars for Cancer
Image of the Day: Fish Avatars for Cancer
The Scientist Staff | Sep 11, 2017
Zebrafish larvae transplanted with patients’ tumors respond as their human donors do to chemotherapy.