animal models

The opportunistic pathogen Klebsiella aerogenes degrades estradiol and induces depressive-like behavior in mice, a study finds.

A reference sequence for this emerging model organism will facilitate research on type 2 diabetes and the health effects of circadian rhythm disruption.

It’s not clear why grain-fed mice are better able to recover after infection, but a study’s findings suggest food type may skew the results of animal studies.

The long-tailed macaque and pig-tailed macaque are now endangered in the wild according to the IUCN Red List, which says exports for monkey research are partially to blame.

Experiments in animals and observations in humans suggest that the amount of proline circulating in one’s plasma has a strong association with depression severity.

Mice rendered infertile through ovary cell–targeting mutations gave birth to seemingly normal offspring through natural mating after a virus-based gene therapy was injected into their ovaries.

Researchers find a way to wipe out the brain’s immune cell corps and send in new and improved versions.

The University of Southern California bioengineer studies how lizards regrow their tails, with the goal of one day inducing regeneration in humans.

Personalized stem cells improved motor symptoms and depression signs in monkeys modeling Parkinson’s disease, paving the way for trials in human patients.

Tracking human cancers in mice shows some unexpected cell changes that could undermine translational research.  

A newly developed platform may one day replace cell culture and animal models to personalize cancer treatment.

The color morph’s bright yellow hue and its propensity for skin tumors both likely stem from a gene implicated in a dangerous form of human skin cancer, suggesting the animals could make an ideal model for studying the disease.

Researchers turn to familiar model animals, along with some fresh strategies, to develop countermeasures against SARS-CoV-2 and investigate the biology of infection.