Researchers turn to familiar model animals, along with some fresh strategies, to develop countermeasures against SARS-CoV-2 and investigate the biology of infection.

The University of Alabama at Birmingham neuroscientist aims to determine which cells are most important in prompting the disease’s initiation and progression.

When mice that had suffered a stroke were given blood from a healthy donor, they experienced less tissue and neurological damage.

The Johns Hopkins University researcher bucked the prevailing idea that the body would not launch an immune response against its own tissues, and in doing so established an entirely new scientific discipline.

A newly engineered synthetic blood vessel offers a novel platform for developing drugs that treat high blood pressure.

The host transcriptional signature elicited by the coronavirus appears to be less robust and lacks the induction of key antiviral genes.

Many researchers have stopped breeding mice, reduced the size of colonies, and established contingency plans in case animal care staff get sick.

Rhesus macaques can be infected with SARS-CoV-2, leading primate center scientists to try to prevent outbreaks in their colonies, especially as experiments on coronavirus start.

It could be a throwback to a mechanism that induces ovulation during sex, researchers propose, but not everyone thinks the results can be extrapolated to people.

The sei ion channel in fruit flies keeps their neuronal excitability in check.

Johns Hopkins’s Ted Dawson discusses his lab’s demonstration that misfolded α-synuclein can move from the stomach to the brain and cause physical and cognitive symptoms.

The move reflects scientists using more cell lines and organoids in genetic research, although some experts disagree with the decision to scale back the use of animal models.

Machine learning could be the key to reducing the use of animals in experiments.

Scientists say that increasingly rigorous licensing procedures have complicated research efforts—and in some cases, stopped experiments completely.