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3D illustration of p53 bound to DNA
One Protein to Rule Them All
p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.
One Protein to Rule Them All
One Protein to Rule Them All

p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.

p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.

animal models

Back Pain Explained
Rachael Moeller Gorman | Feb 5, 2024 | 4 min read
Not all degenerated intervertebral discs are painful; a new study identified a subset of disc cells that triggers a pathway to pain.
Ferret and DNA composition
Ferreting Out the Causes of Cystic Fibrosis
Danielle Gerhard, PhD | Feb 1, 2024 | 2 min read
Transgenic ferret models ratted out how a rare cell type affects airway function.
A microscopy image of intestinal crypts in human tissue.
Trust Your Gut: Screening Drugs Using Novel Intestinal Models
The Scientist and Altis Biosystems | 4 min read
Discover how cutting-edge nonclinical in vitro models better recapitulate the human gastrointestinal tract.
Keeping Kidneys Healthy with a Hand from AI
Aparna Nathan, PhD | Dec 11, 2023 | 3 min read
Researchers found new mechanisms and drug targets for cystinosis.
Rodents Offer New Insights Into the Diversity of Addiction
Aparna Nathan, PhD | Dec 1, 2023 | 4 min read
Molecular studies may point to underlying genetics and therapeutic targets.
Sun
Relevant Models Reflect Real-World Needs
The Scientist | 1 min read
Jie Sun shares how his curiosity, creativity, and motivation to address clinical public health needs steer his research in immunology and infectious disease.
Image of various medical supplies on blue background
Relevant Models Reflect Real-world Needs
Deanna MacNeil, PhD | Aug 1, 2023 | 1 min read
Jie Sun shares how his curiosity, creativity, and motivation to address clinical public health needs steer his research in immunology and infectious disease.
Image of the fly brain (grey) highlighting the population of neurons (pink) to which the gut-secreted peptide CCHa1 signals
A Protein-Rich Diet Helps Mice and Flies Sleep More Soundly: Study
Alejandra Manjarrez, PhD | Mar 24, 2023 | 3 min read
The effect appears to be mediated by a gut-secreted peptide that signals to neurons in the brain that modulate the response to mechanical vibrations.
Learn about hot topics in organoid research
Next-Level Organoids
The Scientist | 1 min read
Researchers use organoid cultures in unique ways to study health and disease.
Two pink-colored, rod-shaped bacteria interacting with a blue-colored human cell
Gut Bacterium Linked to Depression in Premenopause
Alejandra Manjarrez, PhD | Mar 17, 2023 | 2 min read
The opportunistic pathogen Klebsiella aerogenes degrades estradiol and induces depressive-like behavior in mice, a study finds.
A Nile rat sitting atop fruits
Genome Spotlight: Nile Rat (Avicanthis niloticus)
Christie Wilcox, PhD | Nov 23, 2022 | 4 min read
A reference sequence for this emerging model organism will facilitate research on type 2 diabetes and the health effects of circadian rhythm disruption.
Gaining Biological Insights into Brain Development Using Single Cell Technologies
Gaining Biological Insights into Brain Development Using Single Cell Technologies
The Scientist Creative Services Team in collaboration with 10x Genomics | 1 min read
Richard Smith will discuss the importance of ionic flux in in utero neuronal development.
A mouse in front of an open sack of grain.
Mice Fed a Highly Processed Diet Are More Susceptible to the Flu
Alejandra Manjarrez, PhD | Nov 18, 2022 | 3 min read
It’s not clear why grain-fed mice are better able to recover after infection, but a study’s findings suggest food type may skew the results of animal studies.
News feature
Photo of a long-tailed macaque (Macaca fascicularis) sitting on a rock overlooking a large body of water.
What Happens to Science When Model Organisms Become Endangered?
Dan Robitzski | Oct 13, 2022 | 9 min read
The long-tailed macaque and pig-tailed macaque are now endangered in the wild according to the IUCN Red List, which says exports for monkey research are partially to blame.
The Epigenetic Origins of Allergy and Asthma
The Scientist Speaks Ep. 15 - The Epigenetic Origins of Allergy and Asthma
The Scientist | 1 min read
Epigenetic marks acquired from environmental exposures throughout life influence human health and may even transcend generations.
Artist’s rendition of bright blue microbes among intestinal lining
Study Links Depression with High Levels of an Amino Acid
Dan Robitzski | Jun 14, 2022 | 5 min read
Experiments in animals and observations in humans suggest that the amount of proline circulating in one’s plasma has a strong association with depression severity.
A white mouse huddles with some of her nine-day-old pups.
In Vivo Gene Therapy Cures Infertility in Mice
Dan Robitzski | May 2, 2022 | 2 min read
Mice rendered infertile through ovary cell–targeting mutations gave birth to seemingly normal offspring through natural mating after a virus-based gene therapy was injected into their ovaries.
Improving Cardiac Cell Therapy Persistence
The Scientist Speaks Ep. 13 - The Long Haul: Improving Cardiac Cell Therapy Persistence
Niki Spahich, PhD | 1 min read
Researchers remuscularize the heart after cardiac infarction with stem cell-derived cardiomyocytes and ready-made microvessels.
Image of brain cells showing pyramidal neurons in green, astrocytes in red, and microglia in blue
Replacing Microglia Treats Neurodegenerative Disease in Mice
Shawna Williams | Mar 17, 2022 | 2 min read
Researchers find a way to wipe out the brain’s immune cell corps and send in new and improved versions.
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