Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome

In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.

In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.

epigenome
Q&A: A 10,000-Genome Milestone for Shared Pediatric Cancer Data  
Q&A: A 10,000-Genome Milestone for Shared Pediatric Cancer Data  
Carolyn Wilke | Apr 1, 2019
Computational biologist Jinghui Zhang of St. Jude realized scientists could work more efficiently with tools and genomic data shared on the cloud.
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Ashley Yeager | Jan 1, 2019
Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.
Analysis of 2,000 Brains Provides Clues to Schizophrenia, Autism
Analysis of 2,000 Brains Provides Clues to Schizophrenia, Autism
Catherine Offord | Dec 14, 2018
The PsychENCODE project delves into the DNA, RNA, and protein changes related to brain development and neuropsychiatric disorders, but researchers caution it’s just a first step toward treatment.
Study Finds Epigenetic Differences Between Hatchery-Raised and Wild-Born Salmon
Study Finds Epigenetic Differences Between Hatchery-Raised and Wild-Born Salmon
Shawna Williams | Mar 1, 2018
The variation may help explain why stocked salmon don’t fare as well in the ocean.
Exploring the Epigenetics of Ethnicity
Exploring the Epigenetics of Ethnicity
Anna Azvolinsky | Jan 10, 2017
Researchers attempt to estimate how much of the human genome’s methylation patterns can be attributed to genetic ancestry.
Opinion: Engineering the Epigenome
Opinion: Engineering the Epigenome
Anna Köferle, Stefan H. Stricker, Stephan Beck | Aug 26, 2015
The use of targetable chromatin modifiers has ushered in a new era of functional epigenomics.
New Epigenetic Mark Found on Metazoan DNA
New Epigenetic Mark Found on Metazoan DNA
Jenny Rood | Apr 30, 2015
Three studies identify roles for N6-methyladenosine in algae, worms, and flies.
CRISPR–Enabled Epigenome Editing
CRISPR–Enabled Epigenome Editing
Kerry Grens | Apr 6, 2015
Researchers apply the genome-editing technology to alter histones at distant gene enhancers, controlling gene expression.
Exploring the Epigenome
Exploring the Epigenome
Jenny Rood | Feb 18, 2015
A National Institutes of Health-funded consortium publishes 111 reference maps of DNA and histone marks.
Methylation Tied to Alzheimer’s
Methylation Tied to Alzheimer’s
Kerry Grens | Aug 20, 2014
People with the neurodegenerative disease are more likely to have certain epigenetic patterns than those without.
Epigenetic Changes Can Cause Cancer
Epigenetic Changes Can Cause Cancer
Ashley P. Taylor | Jul 25, 2014
A transgene designed to attract methylation to the promoter of a tumor-suppressor gene leads to tumorigenesis in a mouse model. 
Gestational Malnutrition Affects Offspring’s Sperm
Gestational Malnutrition Affects Offspring’s Sperm
Anna Azvolinsky | Jul 10, 2014
Mice undernourished during pregnancy can transmit the effects of such nutritional stress to their sons’ germ cells, epigenetically.  
Brain Methylation Map Published
Brain Methylation Map Published
Kate Yandell | Jul 4, 2013
The epigenetic modification of brain cells undergoes great shifts over the course of mouse and human development.
An Epi Phenomenon
An Epi Phenomenon
Karen Hopkin | Dec 1, 2012
While exploring the genetics of a rare type of tumor, Stephen Baylin discovered an epigenetic modification that occurs in most every cancer—a finding he’s helping bring to the clinic.
Blood Spots Are Epigenetic Time Capsules
Sabrina Richards | Aug 22, 2012
Researchers show that blood spotted onto Guthrie cards, usually at birth, can be a high quality source of methylated DNA for long-term epigenetic studies.
Exercise Alters Epigenetics
Hannah Waters | Mar 6, 2012
Exercise causes short-term changes in DNA methylation and gene expression in muscle tissue that may have implications for type 2 diabetes.
Epigenetic Changes in Cancer
Manel Esteller | Mar 1, 2011
The study of how covalent marks on DNA and histones are involved in the origin and spread of cancer cells is also leading to new therapeutic strategies.