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Discover How Nanopore Sequencing Delivers More Insights into Cancer Genomics
Comprehensive Genomic Analysis Accelerates Cancer Research
Sequencing advances deliver comprehensive insights into how genomic variation drives cancer initiation and progression.
Comprehensive Genomic Analysis Accelerates Cancer Research
Comprehensive Genomic Analysis Accelerates Cancer Research

Sequencing advances deliver comprehensive insights into how genomic variation drives cancer initiation and progression.

Sequencing advances deliver comprehensive insights into how genomic variation drives cancer initiation and progression.

epigenome

Depiction of human DNA helix. 
An Epigenetic Strategy to Control Bad Cholesterol
Maggie Chen | Apr 12, 2024 | 3 min read
Modifying markers on DNA allows scientists to lower cholesterol levels in mice, even long-term.
A DNA sequence represented by its base letters.
Measuring the Genome and Methylome at Single Base Resolution
biomodal | Mar 14, 2024 | 1 min read
Researchers can build models to predict gene expression by detecting and differentiating between cytosine methylation and hydroxymethylation marks in the genome.
Bladder epithelial tissue, where cell junctions are shown in green and nuclei in blue. This was grown in vitro from cells taken from mice with chronic cystitis.
Bladder ‘Memory’ Influences Urinary Tract Infection Recurrence in Mice
Alejandra Manjarrez, PhD | Apr 12, 2023 | 3 min read
Urinary tract infections leave permanent epigenetic marks in the mouse bladder epithelium, reprogramming its response to subsequent infections, a study finds.
Illustration from the epigenetics and the genome infographic
Infographic: How Epigenetic Marks Can Change the Genome
Katarina Zimmer | Nov 1, 2022 | 2 min read
Although epigenetic changes were long thought to largely act on the genome, rather than as part of it, research is now showing that these patterns can, directly or indirectly, change the genetic code.
Cellular DNA and epigenetics
Do Epigenetic Changes Influence Evolution?
Katarina Zimmer | Nov 1, 2022 | 10+ min read
Evidence is mounting that epigenetic marks on DNA can influence future generations in a variety of ways. But how such phenomena might affect large-scale evolutionary processes is hotly debated.
Developing Spatial Multiomic Maps
Technique Talk: Developing Spatial Multiomic Maps
The Scientist | Aug 29, 2022 | 1 min read
Rafael Kramann will discuss spatial transcriptome and epigenome changes to identify injury, repair, and remodeling in myocardial infarction.
Alcohol bottles at a bar
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
Natalia Mesa, PhD | May 20, 2022 | 4 min read
A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.
early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021 | 5 min read
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
Q&A: A 10,000-Genome Milestone for Shared Pediatric Cancer Data  
Carolyn Wilke | Apr 1, 2019 | 3 min read
Computational biologist Jinghui Zhang of St. Jude realized scientists could work more efficiently with tools and genomic data shared on the cloud.
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Ashley Yeager | Jan 1, 2019 | 7 min read
Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.
Analysis of 2,000 Brains Provides Clues to Schizophrenia, Autism
Catherine Offord | Dec 14, 2018 | 2 min read
The PsychENCODE project delves into the DNA, RNA, and protein changes related to brain development and neuropsychiatric disorders, but researchers caution it’s just a first step toward treatment.
Study Finds Epigenetic Differences Between Hatchery-Raised and Wild-Born Salmon
Shawna Williams | Mar 1, 2018 | 4 min read
The variation may help explain why stocked salmon don’t fare as well in the ocean.
Exploring the Epigenetics of Ethnicity
Anna Azvolinsky | Jan 10, 2017 | 4 min read
Researchers attempt to estimate how much of the human genome’s methylation patterns can be attributed to genetic ancestry.
Opinion: Engineering the Epigenome
Anna Köferle, Stefan H. Stricker, and Stephan Beck | Aug 26, 2015 | 3 min read
The use of targetable chromatin modifiers has ushered in a new era of functional epigenomics.
New Epigenetic Mark Found on Metazoan DNA
Jenny Rood | Apr 30, 2015 | 3 min read
Three studies identify roles for N6-methyladenosine in algae, worms, and flies.
CRISPR–Enabled Epigenome Editing
Kerry Grens | Apr 6, 2015 | 1 min read
Researchers apply the genome-editing technology to alter histones at distant gene enhancers, controlling gene expression.
Exploring the Epigenome
Jenny Rood | Feb 18, 2015 | 3 min read
A National Institutes of Health-funded consortium publishes 111 reference maps of DNA and histone marks.
Methylation Tied to Alzheimer’s
Kerry Grens | Aug 20, 2014 | 1 min read
People with the neurodegenerative disease are more likely to have certain epigenetic patterns than those without.
Epigenetic Changes Can Cause Cancer
Ashley P. Taylor | Jul 25, 2014 | 3 min read
A transgene designed to attract methylation to the promoter of a tumor-suppressor gene leads to tumorigenesis in a mouse model. 
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