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Illustration from the epigenetics and the genome infographic
Infographic: How Epigenetic Marks Can Change the Genome
Although epigenetic changes were long thought to largely act on the genome, rather than as part of it, research is now showing that these patterns can, directly or indirectly, change the genetic code.
Infographic: How Epigenetic Marks Can Change the Genome
Infographic: How Epigenetic Marks Can Change the Genome

Although epigenetic changes were long thought to largely act on the genome, rather than as part of it, research is now showing that these patterns can, directly or indirectly, change the genetic code.

Although epigenetic changes were long thought to largely act on the genome, rather than as part of it, research is now showing that these patterns can, directly or indirectly, change the genetic code.

epigenome
Cellular DNA and epigenetics
Do Epigenetic Changes Influence Evolution?
Katarina Zimmer | Nov 1, 2022 | 10+ min read
Evidence is mounting that epigenetic marks on DNA can influence future generations in a variety of ways. But how such phenomena might affect large-scale evolutionary processes is hotly debated.
Alcohol bottles at a bar
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
Natalia Mesa, PhD | May 20, 2022 | 4 min read
A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.
Developing Spatial Multiomic Maps
Technique Talk: Developing Spatial Multiomic Maps
The Scientist’s Creative Services Team | 1 min read
Rafael Kramann will discuss spatial transcriptome and epigenome changes to identify injury, repair, and remodeling in myocardial infarction.
early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021 | 5 min read
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
Q&A: A 10,000-Genome Milestone for Shared Pediatric Cancer Data  
Carolyn Wilke | Apr 1, 2019 | 3 min read
Computational biologist Jinghui Zhang of St. Jude realized scientists could work more efficiently with tools and genomic data shared on the cloud.
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Ashley Yeager | Jan 1, 2019 | 7 min read
Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.
Analysis of 2,000 Brains Provides Clues to Schizophrenia, Autism
Catherine Offord | Dec 14, 2018 | 2 min read
The PsychENCODE project delves into the DNA, RNA, and protein changes related to brain development and neuropsychiatric disorders, but researchers caution it’s just a first step toward treatment.
Study Finds Epigenetic Differences Between Hatchery-Raised and Wild-Born Salmon
Shawna Williams | Mar 1, 2018 | 4 min read
The variation may help explain why stocked salmon don’t fare as well in the ocean.
Exploring the Epigenetics of Ethnicity
Anna Azvolinsky | Jan 10, 2017 | 4 min read
Researchers attempt to estimate how much of the human genome’s methylation patterns can be attributed to genetic ancestry.
Opinion: Engineering the Epigenome
Anna Köferle, Stefan H. Stricker, and Stephan Beck | Aug 26, 2015 | 3 min read
The use of targetable chromatin modifiers has ushered in a new era of functional epigenomics.
New Epigenetic Mark Found on Metazoan DNA
Jenny Rood | Apr 30, 2015 | 3 min read
Three studies identify roles for N6-methyladenosine in algae, worms, and flies.
CRISPR–Enabled Epigenome Editing
Kerry Grens | Apr 6, 2015 | 1 min read
Researchers apply the genome-editing technology to alter histones at distant gene enhancers, controlling gene expression.
Exploring the Epigenome
Jenny Rood | Feb 18, 2015 | 3 min read
A National Institutes of Health-funded consortium publishes 111 reference maps of DNA and histone marks.
Methylation Tied to Alzheimer’s
Kerry Grens | Aug 20, 2014 | 1 min read
People with the neurodegenerative disease are more likely to have certain epigenetic patterns than those without.
Epigenetic Changes Can Cause Cancer
Ashley P. Taylor | Jul 25, 2014 | 3 min read
A transgene designed to attract methylation to the promoter of a tumor-suppressor gene leads to tumorigenesis in a mouse model. 
Gestational Malnutrition Affects Offspring’s Sperm
Anna Azvolinsky | Jul 10, 2014 | 3 min read
Mice undernourished during pregnancy can transmit the effects of such nutritional stress to their sons’ germ cells, epigenetically.  
Brain Methylation Map Published
Kate Yandell | Jul 4, 2013 | 2 min read
The epigenetic modification of brain cells undergoes great shifts over the course of mouse and human development.
An Epi Phenomenon
Karen Hopkin | Dec 1, 2012 | 9 min read
While exploring the genetics of a rare type of tumor, Stephen Baylin discovered an epigenetic modification that occurs in most every cancer—a finding he’s helping bring to the clinic.
Blood Spots Are Epigenetic Time Capsules
Sabrina Richards | Aug 22, 2012 | 3 min read
Researchers show that blood spotted onto Guthrie cards, usually at birth, can be a high quality source of methylated DNA for long-term epigenetic studies.
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