epigenomics

Although epigenetic changes were long thought to largely act on the genome, rather than as part of it, research is now showing that these patterns can, directly or indirectly, change the genetic code.

Evidence is mounting that epigenetic marks on DNA can influence future generations in a variety of ways. But how such phenomena might affect large-scale evolutionary processes is hotly debated.

Single cell and spatial assays provide information on different aspects of cancer.

A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.

Studies The Scientist covered this year illustrate the expanding importance of genetic and genomic research in all aspects of life science, from ecology to medicine.

In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.

The Johns Hopkins University professor was a co-developer of the Galaxy platform, an open-source bioinformatics tool used in labs around the world.

The use of targetable chromatin modifiers has ushered in a new era of functional epigenomics.

Stoned, Anxious, The Deeper Genome, and Testosterone

Generation-spanning maps of Arabidopsis thaliana DNA methylation allow researchers to compute how quickly epigenetic marks appear and disappear in the plant’s genome.

A National Institutes of Health-funded consortium publishes 111 reference maps of DNA and histone marks.

Making sense of the data deluge