As researchers unravel the molecular machinery that links exercise and cognition, working out is emerging as a promising neurotherapy.

Boosting both neurogenesis and a brain-derived growth factor can mimic the cognitive benefits of exercise in a mouse mode of Alzheimer’s disease.

Directly activating a heat sensor also sensitive to capsaicin in chili peppers in the hypothalamus had the same effect as exercise.

Epinephrine’s activation of the signaling pathway Hippo is responsible for the in vitro tumor-fighting effects of serum from women who worked out.

Male rodents given access to a running wheel early in life show increased neural activity and improved memory as adults.

Researchers at the Society for Neuroscience discuss what we know—and don’t—about how physical activity affects the brain.

Endurance exercise and metabolism are linked to transcriptional activation of human telomeres, researchers propose.

Running releases an enzyme that is associated with memory function in mice and humans.
 

At the American Association for Cancer Research annual meeting, researchers review the evidence that exercise has antitumor benefits.