Men given high doses of two antihistamine drugs did not experience the same benefits of high intensity interval training that men on a placebo enjoyed, revealing some of the molecular underpinnings of exercise’s effect.

Healthy people put through high-intensity interval training, or HIIT, displayed insulin resistance and mitochondrial dysfunction after working out excessively.

A study offers a new explanation for how exercise strengthens bones and the immune system.

After weeks of training, the muscles of two macaques exhibited greater responses to stimulation of the reticulospinal tract in the brain stem than they had before, suggesting that strengthening the neural pathway is key to getting stronger. 

A study in two macaques reveals the importance of increasing connectivity between muscles and the reticulospinal tract that runs from the brain stem down the spinal cord.

The researchers behind the results propose that an exercise-induced protein in circulation is responsible for the benefits.

Meet some of the people featured in the April 2020 issue of The Scientist.

Studies point to a role for physical activity in fighting malignancies, improving treatment outcomes, and fostering overall health in patients.

Researchers found that people who spend more time outdoors also spend more time being active and socializing, but it probably doesn’t account for all of the health boost associated with green spaces.

Altering DNA methylation in a particular area of the hypothalamus halved the animals’ voluntary exercise as adults.

Men had better fat-burning results when they had breakfast after cycling instead of beforehand.

New, unpublished results show some of the cells produce new neurons for up to 90 days, much longer than a previously identified set of neural stem cells that only generate neurons for a month or two.

Physical activity, independent of diet, shifts the composition of bacteria in the intestines, spurring researchers to search for species that might provide benefits akin to working out.

A mouse study finds that when blood platelets are activated during exercise, they release factors that increase the number of newborn neurons in the hippocampus.

From cellular self-digestion to the effects of exercise on the brain, our features editor picks her favorite art custom-made for the magazine.

They hope to develop the “exercise hormone” into therapeutics that harness the benefits of exercise for people unable to do so.

Identifying the molecular interactions that occur all over the body during exercise could reveal how it affects learning and memory.

As researchers unravel the molecular machinery that links exercise and cognition, working out is emerging as a promising neurotherapy.

Boosting both neurogenesis and a brain-derived growth factor can mimic the cognitive benefits of exercise in a mouse mode of Alzheimer’s disease.