Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.
Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Putative Exercise Hormone Irisin Boosts Mouse Brainpower

Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.

Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.

exercise
Mechanosensory Protein Helps Tendons Stiffen After Exercise
Mechanosensory Protein Helps Tendons Stiffen After Exercise
Catherine Offord | Sep 1, 2021
Researchers identify a role for PIEZO1 in tendon adaptation, and show that people with certain versions of the Piezo1 gene tend to be better jumpers.
Exercising During Pregnancy Protects Mouse Offspring
Exercising During Pregnancy Protects Mouse Offspring
Jack J. Lee | Aug 1, 2021
Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.
Regular HIIT Exercise Enhances Health via Histamine
Regular HIIT Exercise Enhances Health via Histamine
Rachael Moeller Gorman | Apr 21, 2021
Men given high doses of two antihistamine drugs did not experience the same benefits of high intensity interval training that men on a placebo enjoyed, revealing some of the molecular underpinnings of exercise’s effect.
Extreme Exercise Carries Metabolic Consequences: Study
Extreme Exercise Carries Metabolic Consequences: Study
Shawna Williams | Mar 23, 2021
Healthy people put through high-intensity interval training, or HIIT, displayed insulin resistance and mitochondrial dysfunction after working out excessively.
Impact of Running Reaches Marrow to Spark Bone Growth in Mice
Impact of Running Reaches Marrow to Spark Bone Growth in Mice
Emma Yasinski | Mar 2, 2021
A study offers a new explanation for how exercise strengthens bones and the immune system.
Infographic: How Weight Lifting Changes Monkeys’ Neural Connections
Infographic: How Weight Lifting Changes Monkeys’ Neural Connections
Jef Akst | Oct 1, 2020
After weeks of training, the muscles of two macaques exhibited greater responses to stimulation of the reticulospinal tract in the brain stem than they had before, suggesting that strengthening the neural pathway is key to getting stronger. 
Neural Connections Bolstered in Monkeys That Lift Weights
Neural Connections Bolstered in Monkeys That Lift Weights
Jef Akst | Oct 1, 2020
A study in two macaques reveals the importance of increasing connectivity between muscles and the reticulospinal tract that runs from the brain stem down the spinal cord.
Blood Transplants from Active Mice Give Brain Boost to Others
Blood Transplants from Active Mice Give Brain Boost to Others
Lisa Winter | Jul 12, 2020
The researchers behind the results propose that an exercise-induced protein in circulation is responsible for the benefits.
Contributors
Contributors
The Scientist Staff | Apr 1, 2020
Meet some of the people featured in the April 2020 issue of The Scientist.
Regular Exercise Helps Patients Combat Cancer
Regular Exercise Helps Patients Combat Cancer
Bente Klarlund Pedersen | Apr 1, 2020
Studies point to a role for physical activity in fighting malignancies, improving treatment outcomes, and fostering overall health in patients.
Can Exercise Explain the Health Benefits of Natural Environments?
Can Exercise Explain the Health Benefits of Natural Environments?
Emily Makowski | Jan 3, 2020
Researchers found that people who spend more time outdoors also spend more time being active and socializing, but it probably doesn’t account for all of the health boost associated with green spaces.
Early Epigenetic Changes Regulate Voluntary Exercise in Mice: Study
Early Epigenetic Changes Regulate Voluntary Exercise in Mice: Study
Emma Yasinski | Dec 7, 2019
Altering DNA methylation in a particular area of the hypothalamus halved the animals’ voluntary exercise as adults.
Exercising Before Eating Burns More Fat: Study
Exercising Before Eating Burns More Fat: Study
Emily Makowski | Nov 27, 2019
Men had better fat-burning results when they had breakfast after cycling instead of beforehand.
Long-Lived Neural Stem Cells Identified in Living Mice
Long-Lived Neural Stem Cells Identified in Living Mice
Ashley Yeager | Oct 22, 2019
New, unpublished results show some of the cells produce new neurons for up to 90 days, much longer than a previously identified set of neural stem cells that only generate neurons for a month or two.
Exercise Changes Our Gut Microbes, But How Isn’t Yet Clear
Exercise Changes Our Gut Microbes, But How Isn’t Yet Clear
Ashley Yeager | Aug 15, 2019
Physical activity, independent of diet, shifts the composition of bacteria in the intestines, spurring researchers to search for species that might provide benefits akin to working out.
A New Role for Platelets: Boosting Neurogenesis After Exercise
A New Role for Platelets: Boosting Neurogenesis After Exercise
Katarina Zimmer | Mar 21, 2019
A mouse study finds that when blood platelets are activated during exercise, they release factors that increase the number of newborn neurons in the hippocampus.
<em>The Scientist</em>&rsquo;s Most Stunning Infographics of 2018
The Scientist’s Most Stunning Infographics of 2018
Jef Akst | Dec 21, 2018
From cellular self-digestion to the effects of exercise on the brain, our features editor picks her favorite art custom-made for the magazine.
Researchers Identify Irisin&rsquo;s Receptor in Bone and Fat
Researchers Identify Irisin’s Receptor in Bone and Fat
Carolyn Wilke | Dec 13, 2018
They hope to develop the “exercise hormone” into therapeutics that harness the benefits of exercise for people unable to do so.
Infographic: Exercise&rsquo;s Effects on the Brain
Infographic: Exercise’s Effects on the Brain
Ashley Yeager | Nov 1, 2018
Identifying the molecular interactions that occur all over the body during exercise could reveal how it affects learning and memory.