JFT1 has reacted with hydrogen peroxide and APEX2 to create red fluorescence near APEX2 that remains separate from the green mitochondria.
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A modified fluorescent protein scheme survives harsh electron microscopy conditions, offering new solutions for dual imaging.

fluorescent protein

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

Certain Color Varieties of a Coral Are More Protected from Bleaching

Researchers Produce Alpaca Antibodies Using Yeast

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June 2025, Issue 1

Nergal Networks: Where Friendship Meets Infection

A citizen science game explores how social choices and networks can influence how an illness moves through a population.

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Waters Enhances Alliance iS HPLC System Software, Setting a New Standard for End-to-End Traceability and Data Integrity 

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Agilent Unveils the Next Generation in LC-Mass Detection: The InfinityLab Pro iQ Series

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