JFT1 has reacted with hydrogen peroxide and APEX2 to create red fluorescence near APEX2 that remains separate from the green mitochondria.
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A modified fluorescent protein scheme survives harsh electron microscopy conditions, offering new solutions for dual imaging.

fluorescent protein

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

Certain Color Varieties of a Coral Are More Protected from Bleaching

Researchers Produce Alpaca Antibodies Using Yeast

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Postdoc Portrait: Rohita Roy

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From Data to Discovery: Omics in Therapeutic Innovation

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Exploring Organoids for Disease Modeling Research

February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

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Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

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Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

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Maximizing Cancer Research Model Systems

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Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

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Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies