JFT1 has reacted with hydrogen peroxide and APEX2 to create red fluorescence near APEX2 that remains separate from the green mitochondria.

| 1 min read

FLEXing a Bright New Idea

A modified fluorescent protein scheme survives harsh electron microscopy conditions, offering new solutions for dual imaging.

A cell with gold particles inside is hit with a red laser.

| 10+ min read

How Flow Cytometry Revolutionized Cell Biology Research

Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.

| 10+ min read

Serendipity, Happenstance, and Luck: The Making of a Molecular Tool

fluorescent protein

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Amanda Heidt | | 2 min read

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

Amanda Heidt | | 3 min read

Certain Color Varieties of a Coral Are More Protected from Bleaching

Lisa Winter | | 2 min read

Researchers Produce Alpaca Antibodies Using Yeast

Catherine Offord | | 2 min read

Image of the Day: Hippocampal Jalapeno

The Scientist | | 1 min read

Image of the Day: A Heart is Born

The Scientist | | 1 min read

Notable Science Quotes

The Scientist | | 2 min read

Nobel Laureate Roger Tsien Dies

Kerry Grens | | 2 min read

Updated Tissue-Clearing Protocol Extends Time Frame for Imaging

Kerry Grens | | 1 min read

Grab ’n’ Glow

Ruth Williams | | 3 min read

Predicting Worm Lifespan

Jef Akst | | 1 min read

Glowing Green Eel

Chris Palmer | | 2 min read

What Ever Happened to Douglas Prasher?

Bob Grant | | 4 min read

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DayGlo Science

Laura Geggel | | 4 min read

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Live and In Color

Sarah WebbandKnowable Magazine | | 7 min read

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Encrypting E. coli

Kerry Grens | | 3 min read

Page 1 of 1 - 19 Total Items

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Image of Atul Butte.

Biomedical Informatician Atul Butte Dies at 55

Atul Butte mined big data to fuel biomedical insights to advance precision medicine.

An illustration showing the accumulation of amyloid plaques between nerve cells, which is the underlying cause of disorders like Alzheimer’s and Parkinson’s disease.

A Gut Pathogen’s Unexpected Weapon Against Amyloid Diseases

A protein from Helicobacter pylori inhibits amyloid formation in both microbes and humans, offering new leads for antimicrobial and neurodegenerative disease therapies.

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Universe 25 Experiment

A series of rodent experiments showed that even with abundant food and water, personal space is essential to prevent societal collapse, but Universe 25's relevance to humans remains disputed.

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The Genes That Shaped Pets and Domesticated Livestock

Comparative genomics revealed genetic differences between wild and domestic animals, highlighting traits influenced by human selection.

Multimedia

Explore synthetic DNA’s many applications in cancer research

Weaving the Fabric of Cancer Research with Synthetic DNA

Modern DNA synthesis platforms empower researchers to explore the molecular world, from next-generation sequencing to cell and gene therapy development.

Two images of U2OS cells transfected with a fluorescently labeled protein. The left panel shows AI-based analysis of transfection efficiency, with cells bounded in yellow and label marked in magenta. The right panel shows baseline fluorescence.

Leveraging AI for Analyzing Cell Transfection Efficiency

Explore how AI can provide more accurate and reliable measurements of transfection success rate.

Image of small blue creatures called Nergals. Some have hearts above their heads, which signify friendship. There is one Nergal who is sneezing and losing health, which is denoted by minus one signs floating around it.

June 2025, Issue 1

Nergal Networks: Where Friendship Meets Infection

A citizen science game explores how social choices and networks can influence how an illness moves through a population.

View this Issue

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Explore synthetic DNA’s many applications in cancer research

Weaving the Fabric of Cancer Research with Synthetic DNA

Modern DNA synthesis platforms empower researchers to explore the molecular world, from next-generation sequencing to cell and gene therapy development.

Illustrated plasmids in bright fluorescent colors

Enhancing Elution of Plasmid DNA

An improved chromatography membrane elution method helps scientists achieve higher yields of pure plasmid DNA.

An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

By fine-tuning polishing conditions, scientists attain high titers of infectious lentiviral particles during purification.

Explore new strategies for improving plasmid DNA manufacturing workflows.

Overcoming Obstacles in Plasmid DNA Manufacturing

Discover a scalable and flexible GMP-compliant workflow for producing plasmid DNA.

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Waters Enhances Alliance iS HPLC System Software, Setting a New Standard for End-to-End Traceability and Data Integrity

Industry-first smart HPLC system to provide authenticated user access verification on onboard touchscreen for superior security.

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Agilent Unveils the Next Generation in LC-Mass Detection: The InfinityLab Pro iQ Series

Setting new standards for intelligent mass detection, sensitivity, and sustainability.

Agilent Announces the Enhanced 8850 Gas Chromatograph

Compact, Powerful, and now Mass Spec-Connected for Superior Analytical Performance

Pioneering Cancer Plasticity Atlas will help Predict Response to Cancer Therapies

The Wellcome Sanger Institute, Helmholtz Munich, and Parse Biosciences have announced a landmark international collaboration to create a Cancer Plasticity Atlas.