maternal-fetal interactions

Male placentas produce more proinflammatory molecules than female placentas, while people carrying male fetuses produce fewer antibodies in response to infection, a study finds.

Genes associated with preterm birth and protecting the fetus from the mother’s immune system appear to be regulated by HAND2.

Work in rodents shows that the bacteria living in a mother’s gut can produce immunomodulatory metabolites and influence the production of maternal antibodies—both of which can affect her offspring’s development.

Bacteria in the gut influence the production of antibodies and themselves secrete metabolites. In a pregnant woman, these compounds may influence immune development of her fetus.

Signaling pathways triggered by the mother’s immune system may cause complications during fetal development.

Study of 81 six-week-olds who were born by C-section or vaginal delivery didn’t show differences in the structure or function of their microbiota, despite contrary results from other studies on babies. 

The maternal gut microbiome guides neo- and postnatal immune system development, a mouse study shows. 

The animal world is full of clever solutions to bioengineering challenges.

Meet some of the people featured in the August 2015 issue of The Scientist.