Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.

In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.

Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.

This year’s most captivating illustrations tell stories from the micro scale—such as newborn neurons in the adult brain and bacteria in the infant gut—to the scale of entire ecosystems, including reintroduced predators and rising seas.

In mice, the brain’s main glial cell type exhibits distinctive patterns of activity across the sleep-wake cycle and influences the response to sleep deprivation.

Adult neurogenesis, already appreciated for its role in learning and memory, also participates in mental health and possibly even attention, new research suggests.

Cutting-edge microscopy is revealing how new neurons made in adult mice’s brains tap into existing neuronal connections.

Strategies to make lab animals forget, remember, or experience false recollections probe how memory works, and may inspire treatments for neurological diseases.

Two rodent models of glaucoma have defects in the waste drainage system.