Image of brain cells showing pyramidal neurons in green, astrocytes in red, and microglia in blue
Replacing Microglia Treats Neurodegenerative Disease in Mice
Researchers find a way to wipe out the brain’s immune cell corps and send in new and improved versions.
ABOVE: © ISTOCK.COM, SELVANEGRA
Replacing Microglia Treats Neurodegenerative Disease in Mice
Replacing Microglia Treats Neurodegenerative Disease in Mice

Researchers find a way to wipe out the brain’s immune cell corps and send in new and improved versions.

Researchers find a way to wipe out the brain’s immune cell corps and send in new and improved versions.

ABOVE: © ISTOCK.COM, SELVANEGRA

mouse brain

mice on wheel and ground
Exercise-Associated Protein Boosts Brain Function in Mice
Chloe Tenn | Dec 9, 2021
A study that transfused plasma from active to inactive mice suggests the protein clusterin enhances cognition.
Image of nerve fibers shown in green and red
Neurons Simplify Visual Signals by Responding to Only One Retina
Anne N. Connor | Oct 1, 2021
Mice have neurons that connect to both eyes but only propagate the signal from one or the other, simplifying the information sent to the cerebral cortex.
Photograph of a mouse covering his face with his paw.
Bless You: Mouse Model Reveals Molecular Pathway Behind Sneezing
Amanda Heidt | Oct 1, 2021
Researchers have identified specific cells and neuropeptides involved in mediating the sneeze response in mice exposed to allergens or chemical irritants such as capsaicin.
Illustration showing how a mouse study identifies the brain regions and specific signaling factors that regulate the sneeze response.
Infographic: The Neural Pathway of Sneezing
Amanda Heidt | Oct 1, 2021
A mouse study identifies the brain regions and specific signaling factors that regulate the sneeze response.
One white mouse with red eyes runs on a blue exercise wheel, while another mouse stands with front paws on the wheel
Serious Infections Linked to Autism: Study
Abby Olena | Sep 17, 2021
In both a mouse model and the hospital records of more than 3 million children, researchers found a connection between strong immune activation in males and later symptoms of autism spectrum disorder.
A multicolored section of a fruit fly brain
Tumors Disrupt the Blood-Brain Barrier at a Distance
Abby Olena | Sep 9, 2021
Shoring up the tissues that separate neurons and other brain cells from the circulatory system in fruit flies and mice can prolong life in the presence of a tumor.
Red blood vessels that decrease in diameter as they radiate outward are pictured on a pink and white surface
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Abby Olena | Aug 18, 2021
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
Two oligodendrocyte progenitor cells are being generated from adult stem cells nestled on the surface of brain ventricle
Scientists Discover “Gorditas” and Other Novel Brain Cell Types
Amanda Heidt | Jun 10, 2021
A pool of neural stem cells that ordinarily lies dormant in the brains of adult mice spawns two types of never-before-documented glial cells when artificially reactivated, potentially pointing to a novel mechanism of brain plasticity.
A microscopy image of a mouse brain that shows the lymphatic system in bright purple and pink
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Amanda Heidt | May 4, 2021
A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.
Anesthesia Impairs Memory in Mice
Abby Olena | Apr 1, 2021
A study that compared several anesthetic regimens in rodents showed that only one—inhaled isoflurane—wasn’t detrimental to the activity of neurons in the hippocampus.
neutrobots, neutrophils, white blood cells, microrobots, nanorobots, microbots, glioma, brain cancer, paclitaxel, magnetic, swarm, mice
Microscopic Robots Deliver Drugs to the Brain
Asher Jones | Mar 30, 2021
Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.
early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
A Tweak to Immune Cells Reverses Aging in Mice
Abby Olena | Jan 20, 2021
Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.
Editor’s Picks of The Scientist’s Best Infographics of 2020
Jef Akst | Dec 15, 2020
This year’s most captivating illustrations tell stories from the micro scale—such as newborn neurons in the adult brain and bacteria in the infant gut—to the scale of entire ecosystems, including reintroduced predators and rising seas.
Astrocytes, Not Just Neurons, Play a Role in Sleep
Abby Olena | Sep 24, 2020
In mice, the brain’s main glial cell type exhibits distinctive patterns of activity across the sleep-wake cycle and influences the response to sleep deprivation.
What Do New Neurons in the Brains of Adults Actually Do?
Ashley Yeager | May 1, 2020
Adult neurogenesis, already appreciated for its role in learning and memory, also participates in mental health and possibly even attention, new research suggests.
Infographic: How Adult-Born Neurons Integrate into the Brain
Ashley Yeager | May 1, 2020
Cutting-edge microscopy is revealing how new neurons made in adult mice’s brains tap into existing neuronal connections.
How Manipulating Rodent Memories Can Elucidate Neurological Function
Amber Dance | May 1, 2020
Strategies to make lab animals forget, remember, or experience false recollections probe how memory works, and may inspire treatments for neurological diseases.
Quasi-Lymphatic System in the Rodent Eye Clears Waste
Abby Olena | Apr 16, 2020
Two rodent models of glaucoma have defects in the waste drainage system.