Scientists Discover “Gorditas” and Other Novel Brain Cell Types
Scientists Discover “Gorditas” and Other Novel Brain Cell Types
A pool of neural stem cells that ordinarily lies dormant in the brains of adult mice spawns two types of never-before-documented glial cells when artificially reactivated, potentially pointing to a novel mechanism of brain plasticity.
Scientists Discover “Gorditas” and Other Novel Brain Cell Types
Scientists Discover “Gorditas” and Other Novel Brain Cell Types

A pool of neural stem cells that ordinarily lies dormant in the brains of adult mice spawns two types of never-before-documented glial cells when artificially reactivated, potentially pointing to a novel mechanism of brain plasticity.

A pool of neural stem cells that ordinarily lies dormant in the brains of adult mice spawns two types of never-before-documented glial cells when artificially reactivated, potentially pointing to a novel mechanism of brain plasticity.

mouse brain
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Amanda Heidt | May 4, 2021
A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.
Anesthesia Impairs Memory in Mice
Anesthesia Impairs Memory in Mice
Abby Olena | Apr 1, 2021
A study that compared several anesthetic regimens in rodents showed that only one—inhaled isoflurane—wasn’t detrimental to the activity of neurons in the hippocampus.
Microscopic Robots Deliver Drugs to the Brain
Microscopic Robots Deliver Drugs to the Brain
Asher Jones | Mar 30, 2021
Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
A Tweak to Immune Cells Reverses Aging in Mice
A Tweak to Immune Cells Reverses Aging in Mice
Abby Olena | Jan 20, 2021
Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.
Editor&rsquo;s Picks of <em>The Scientist</em>&rsquo;s Best Infographics of 2020
Editor’s Picks of The Scientist’s Best Infographics of 2020
Jef Akst | Dec 15, 2020
This year’s most captivating illustrations tell stories from the micro scale—such as newborn neurons in the adult brain and bacteria in the infant gut—to the scale of entire ecosystems, including reintroduced predators and rising seas.
Astrocytes, Not Just Neurons, Play a Role in Sleep
Astrocytes, Not Just Neurons, Play a Role in Sleep
Abby Olena | Sep 24, 2020
In mice, the brain’s main glial cell type exhibits distinctive patterns of activity across the sleep-wake cycle and influences the response to sleep deprivation.
What Do New Neurons in the Brains of Adults Actually Do?
What Do New Neurons in the Brains of Adults Actually Do?
Ashley Yeager | May 1, 2020
Adult neurogenesis, already appreciated for its role in learning and memory, also participates in mental health and possibly even attention, new research suggests.
Infographic: How Adult-Born Neurons Integrate into the Brain
Infographic: How Adult-Born Neurons Integrate into the Brain
Ashley Yeager | May 1, 2020
Cutting-edge microscopy is revealing how new neurons made in adult mice’s brains tap into existing neuronal connections.
How Manipulating Rodent Memories Can Elucidate Neurological Function
How Manipulating Rodent Memories Can Elucidate Neurological Function
Amber Dance | May 1, 2020
Strategies to make lab animals forget, remember, or experience false recollections probe how memory works, and may inspire treatments for neurological diseases.
Quasi-Lymphatic System in the Rodent Eye Clears Waste
Quasi-Lymphatic System in the Rodent Eye Clears Waste
Abby Olena | Apr 16, 2020
Two rodent models of glaucoma have defects in the waste drainage system.
Image of the Day: Brain Map
Image of the Day: Brain Map
Nicoletta Lanese | Sep 6, 2019
Scientists traced 1,000 neurons through the mouse brain, uncovering new details about how the organ is wired.
Image of the Day: Smartphone-Controlled Brains
Image of the Day: Smartphone-Controlled Brains
Nicoletta Lanese | Aug 7, 2019
A device implanted into mice can modulate brain circuit activity over long periods of time.
Brain&rsquo;s Fluid Drains via Lymphatic Vessels at the Base of the Skull
Brain’s Fluid Drains via Lymphatic Vessels at the Base of the Skull
Abby Olena | Jul 24, 2019
Detailed imaging of the rodent central nervous system reveals new information about the route cerebrospinal fluid takes to leave the brain.
Image of the Day: Multicolor Brain
Image of the Day: Multicolor Brain
Chia-Yi Hou | Apr 22, 2019
A newly developed imaging technology visualizes entire mouse brains in two and three dimensions using multicolor fluorescence microscopy.
Rapidly Flashing Lights and Sounds Reduces Alzheimer&rsquo;s in Mice
Rapidly Flashing Lights and Sounds Reduces Alzheimer’s in Mice
Jef Akst | Mar 15, 2019
Exposing mice to an hour of 40-hertz stimuli every day for a week reduced levels of amyloid-β plaques and tau protein, and improved cognition.
Nanoparticles Let Mice See Near Infrared Light
Nanoparticles Let Mice See Near Infrared Light
Abby Olena | Feb 28, 2019
Researchers injected the retinas of mice with nanoparticles that bound to photoreceptors and converted near-infrared light to green light that the animals could see.
Image of the Day: Memory Jogger
Image of the Day: Memory Jogger
Sukanya Charuchandra | Jun 12, 2018
Scientists can livestream how the mouse brain’s hippocampus maps the physical world and accesses those memories.  
Image of the Day: Cooking Up Neurons
Image of the Day: Cooking Up Neurons
The Scientist Staff, The Scientist Staff | May 11, 2018
Using different combinations of transcription factors, researchers create a diverse array of neurons from mouse skin cells.