Shoring up the tissues that separate neurons and other brain cells from the circulatory system in fruit flies and mice can prolong life in the presence of a tumor.

RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.

A pool of neural stem cells that ordinarily lies dormant in the brains of adult mice spawns two types of never-before-documented glial cells when artificially reactivated, potentially pointing to a novel mechanism of brain plasticity.

A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.

A study that compared several anesthetic regimens in rodents showed that only one—inhaled isoflurane—wasn’t detrimental to the activity of neurons in the hippocampus.

Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.

In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.

Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.

This year’s most captivating illustrations tell stories from the micro scale—such as newborn neurons in the adult brain and bacteria in the infant gut—to the scale of entire ecosystems, including reintroduced predators and rising seas.

In mice, the brain’s main glial cell type exhibits distinctive patterns of activity across the sleep-wake cycle and influences the response to sleep deprivation.

Adult neurogenesis, already appreciated for its role in learning and memory, also participates in mental health and possibly even attention, new research suggests.

Cutting-edge microscopy is revealing how new neurons made in adult mice’s brains tap into existing neuronal connections.

Strategies to make lab animals forget, remember, or experience false recollections probe how memory works, and may inspire treatments for neurological diseases.

Two rodent models of glaucoma have defects in the waste drainage system.

Scientists traced 1,000 neurons through the mouse brain, uncovering new details about how the organ is wired.

A device implanted into mice can modulate brain circuit activity over long periods of time.

Detailed imaging of the rodent central nervous system reveals new information about the route cerebrospinal fluid takes to leave the brain.

A newly developed imaging technology visualizes entire mouse brains in two and three dimensions using multicolor fluorescence microscopy.

Exposing mice to an hour of 40-hertz stimuli every day for a week reduced levels of amyloid-β plaques and tau protein, and improved cognition.