Conceptual image of blue neurons with glowing segments over blue background.
CRACK Method Reveals Novel Neuron Type in Mouse Brain
A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.
ABOVE: © istock.com, ismagilov
CRACK Method Reveals Novel Neuron Type in Mouse Brain
CRACK Method Reveals Novel Neuron Type in Mouse Brain

A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.

A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.

ABOVE: © istock.com, ismagilov

neuroimaging

Illustration showing how calcium imaging and HCR-FISH combined is a technique called comprehensive readout of activity and cell type markers (CRACK)
Infographic: Simultaneously Studying Neuron Structure and Function
Dan Robitzski | Apr 18, 2022
A new methodology combines existing techniques to reveal the specific function and location of multiple types of neurons at once.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist Staff | Dec 1, 2021
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Curiosity and Hunger Are Driven by the Same Brain Regions
Shawna Williams | Oct 1, 2020
Researchers tease out the effects of the two cravings by having participants gamble for the chance to satisfy them.
fear, anxiety, fMRI, study, neural circuits, brain study, neuroscience, amygdala, BNST
Brain Circuitry for Fear and Anxiety Is the Same on fMRI
Amanda Heidt | Sep 21, 2020
A study in people fails to detect differences in the brain’s response to fear or anxiety, long thought to be controlled by different neural circuits.
a cartoon of a human head with arrows going in different directions and speech bubble that say "yes!" and "no!"
Research Teams Reach Different Results From Same Brain-Scan Data
Ruth Williams | May 20, 2020
When 70 independent teams were tasked with analyzing identical brain images, no two teams chose the same approach and their conclusions were highly variable.
Scientists Predict Fish Behavior from Real-Time Brain Monitoring
Abby Olena | Jan 22, 2020
Researchers could anticipate which way an eight-day-old zebrafish will flick its tail based on brain activity 10 seconds earlier.
New Tissue Clearing Methods Offer a Window into the Brain
Andy Tay | Oct 1, 2019
Researchers are developing a variety of approaches for clearing neural tissue to get a better view of the brain’s circuitry.
mri fmri neuroscience genetics cognition
Replication Refutes Study Linking Neuroimaging to Genetics
Emma Yasinski | Sep 30, 2019
The original experiment found brain activity as measured by fMRI was tied to particular genetic variants.
SLAP microscope
Image of the Day: Super Speedy Microscopy
Nicoletta Lanese | Aug 9, 2019
Two-photon imaging captures chemical signaling between live mouse neurons on a millisecond timescale.
Neural Circuit of Parental Behavior Mapped in Mice
Jim Daley | Apr 12, 2018
This is the first time the precise brain cells and their connections controlling a complex behavior have been worked out. 
Image of the Day: Mosquito Brain
The Scientist Staff | Mar 6, 2018
Researchers have constructed the first neuroanatomy atlas of a female mosquito’s brain.
Image of the Day: Calcium Signaling
The Scientist Staff, The Scientist Staff | Feb 20, 2018
Researchers used light-sheet microscopy to form 3-D images of the process in primary cortical neurons from embryonic rats.
Image of the Day: Red Alert
The Scientist Staff, The Scientist Staff | Nov 9, 2017
Researchers unveil the neural basis of alertness in larval zebrafish.   
Image of the Day: Fragile X
The Scientist Staff, The Scientist Staff | Nov 7, 2017
Researchers uncover the central role of a protein linked to Fragile X Syndrome in mice, one of the leading causes of autism and intellectual disability.
Image of the Day: Tadpole Prism
The Scientist Staff, The Scientist Staff | Nov 3, 2017
Scientists are making use of Xenopus tadpoles to study autism risk genes. 
Image of the Day: Fish Eye Lens
The Scientist Staff, The Scientist Staff | Nov 1, 2017
Researchers develop a new method to highlight specific cells that reside in the lens of a zebrafish.
Lighting Up Monkey Brains
Jyoti Madhusoodanan | Nov 1, 2017
Optogenetic and chemogenetic tools illuminate brain and behavior connections in nonhuman primates.
Image of the Day: Painting with Viruses
The Scientist Staff, The Scientist Staff | Oct 31, 2017
Researchers have used a modified rabies virus and fluorescent proteins to tag individual nerve cells in the mouse visual cortex. 
Image of the Day: Fear Center
The Scientist Staff, The Scientist Staff | Oct 26, 2017
A set of neurons in the brain’s central amygdala plays a key role in forming memories of aversive experiences, scientists find in mice.