pluripotency

By removing a single gene, researchers change the developmental fate of tumor cells in mice.  

Researchers use the technique to turn on Oct4 or Sox2 in mouse embryonic fibroblasts and convert them into pluripotent cells. 

Combining gene editing and stem-cell induction improves efficiency of functional genetic analyses.

New technologies reveal the dynamic changes in mouse and human embryos during the first week after fertilization.

The switch from maternal factors involves dynamic reprogramming of the zygotic genome.

Activating genes for reprogramming factors for a short time transforms large numbers of differentiated cells into multipotent forms that could be useful for cell-based therapies.

OCT4 is necessary for blastocyst formation in the human embryo, researchers report.

Since their introduction to the lab, pluripotent stem cells have gone from research tool to therapeutic, but the journey has been rocky.

Researchers isolate an easy-to-manipulate, stable, and spatially distinct pluripotent cell type.  

Early versions of two now-retracted stimulus-triggered acquisition of pluripotency studies had been rejected before.  

The authors of a 2008 Nature paper have retracted it after new data watered down the conclusions.

From human induced pluripotent stem cells, researchers grow 3-D retinal tissue that can sense light. 

An investigating committee at Japan’s RIKEN research center finds evidence of falsification and fabrication in two recent Nature papers that touted a new way to induce pluripotency.

Stem cells supposedly derived by the new method of stimulus-induced acquisition of pluripotency may have come from mouse strains other than those claimed.

Nearly two months after researchers published papers showing that they could induce pluripotency with an external stressor, the work’s validity is still being challenged.

Once believed to be irrevocably differentiated, mature cells are now proving to be flexible, able to switch identities with relatively simple manipulation.

Using mouse genes, researchers partially transform differentiated, non-mammalian cells into pluripotent stem cells.

From basic research to beneficial therapies