By removing a single gene, researchers change the developmental fate of tumor cells in mice.  

Researchers use the technique to turn on Oct4 or Sox2 in mouse embryonic fibroblasts and convert them into pluripotent cells. 

Combining gene editing and stem-cell induction improves efficiency of functional genetic analyses.

New technologies reveal the dynamic changes in mouse and human embryos during the first week after fertilization.

The switch from maternal factors involves dynamic reprogramming of the zygotic genome.

Activating genes for reprogramming factors for a short time transforms large numbers of differentiated cells into multipotent forms that could be useful for cell-based therapies.

OCT4 is necessary for blastocyst formation in the human embryo, researchers report.

Since their introduction to the lab, pluripotent stem cells have gone from research tool to therapeutic, but the journey has been rocky.

Researchers isolate an easy-to-manipulate, stable, and spatially distinct pluripotent cell type.  

Early versions of two now-retracted stimulus-triggered acquisition of pluripotency studies had been rejected before.