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Thousands of Mutations Accumulate in the Human Brain Over a Lifetime
Ruth Williams | Dec 7, 2017
Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death.
Opinion: How to Define Cell Type
Fred H. Gage, Sara B. Linker, Tracy A. Bedrosian | Nov 1, 2017
Advances in single-cell technologies have revealed vast differences between cells once thought to be in the same category, calling into question how we define cell type in the first place.
234-Year-Old Tree Has Impressively Stable Genome
Jef Akst | Jun 20, 2017
Genomic analysis of an oak tree that lived during Napoleon’s time supports the idea that plants somehow avoid the accumulation of mutations in their stem cells.
DNA Replication Errors Contribute to Cancer Risk
Anna Azvolinsky | Mar 23, 2017
A follow-up study confirms that random mutations acquired during normal stem cell division likely play a major role in cancer incidence.
Abundant Sequence Errors in Public Databases
Ruth Williams | Feb 16, 2017
A new algorithm reveals hoards of preparation-induced DNA mutations in publicly available human sequences.
Smoking-Linked Cancer Mutations Mapped
Anna Azvolinsky | Nov 3, 2016
Scientists produce a detailed genomic map of mutations and epigenetic changes associated with smoking tobacco across 17 tumor types.
Sequencing Reveals Genomic Diversity of the Human Brain
Ben Andrew Henry | Sep 16, 2016
Researchers examine the role of long interspersed element-1 retrotransposition in neuronal mosaicism.
Monitoring Mitochondrial Mutations
Catherine Offord | Apr 17, 2016
Induced pluripotent stem cells—particularly those generated from older patients—should be screened for defects in mitochondrial DNA, a study shows.
Low Mutation Rate in iPSCs
Catherine Offord | Apr 10, 2016
The mutation rate in induced pluripotent stem cells is 10 times lower than in somatic cells, scientists show.
Mosaic Mutations May Not Be Rare
Anna Azvolinsky | Jun 5, 2015
Somatic mosaicism may be responsible for a larger proportion of genomic variability within humans than previously thought.