Q&A: How Animals Change in Space
Q&A: How Animals Change in Space
Weill Cornell Medicine geneticist Christopher Mason speaks with The Scientist about a bolus of new work on the physiological, cellular, and molecular effects of leaving Earth.
Q&A: How Animals Change in Space
Q&A: How Animals Change in Space

Weill Cornell Medicine geneticist Christopher Mason speaks with The Scientist about a bolus of new work on the physiological, cellular, and molecular effects of leaving Earth.

Weill Cornell Medicine geneticist Christopher Mason speaks with The Scientist about a bolus of new work on the physiological, cellular, and molecular effects of leaving Earth.

somatic mutations
Thousands of Mutations Accumulate in the Human Brain Over a Lifetime
Thousands of Mutations Accumulate in the Human Brain Over a Lifetime
Ruth Williams | Dec 7, 2017
Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death.
Opinion: How to Define Cell Type
Opinion: How to Define Cell Type
Fred H. Gage, Sara B. Linker, Tracy A. Bedrosian | Nov 1, 2017
Advances in single-cell technologies have revealed vast differences between cells once thought to be in the same category, calling into question how we define cell type in the first place.
234-Year-Old Tree Has Impressively Stable Genome
234-Year-Old Tree Has Impressively Stable Genome
Jef Akst | Jun 20, 2017
Genomic analysis of an oak tree that lived during Napoleon’s time supports the idea that plants somehow avoid the accumulation of mutations in their stem cells.
DNA Replication Errors Contribute to Cancer Risk
DNA Replication Errors Contribute to Cancer Risk
Anna Azvolinsky | Mar 23, 2017
A follow-up study confirms that random mutations acquired during normal stem cell division likely play a major role in cancer incidence.
Abundant Sequence Errors in Public Databases
Abundant Sequence Errors in Public Databases
Ruth Williams | Feb 16, 2017
A new algorithm reveals hoards of preparation-induced DNA mutations in publicly available human sequences.
Smoking-Linked Cancer Mutations Mapped
Smoking-Linked Cancer Mutations Mapped
Anna Azvolinsky | Nov 3, 2016
Scientists produce a detailed genomic map of mutations and epigenetic changes associated with smoking tobacco across 17 tumor types. 
Sequencing Reveals Genomic Diversity of the Human Brain
Sequencing Reveals Genomic Diversity of the Human Brain
Ben Andrew Henry | Sep 16, 2016
Researchers examine the role of long interspersed element-1 retrotransposition in neuronal mosaicism.
Monitoring Mitochondrial Mutations
Monitoring Mitochondrial Mutations
Catherine Offord | Apr 17, 2016
Induced pluripotent stem cells—particularly those generated from older patients—should be screened for defects in mitochondrial DNA, a study shows.
Low Mutation Rate in iPSCs
Low Mutation Rate in iPSCs
Catherine Offord | Apr 10, 2016
The mutation rate in induced pluripotent stem cells is 10 times lower than in somatic cells, scientists show.
Mosaic Mutations May Not Be Rare
Mosaic Mutations May Not Be Rare
Anna Azvolinsky | Jun 5, 2015
Somatic mosaicism may be responsible for a larger proportion of genomic variability within humans than previously thought.
Personalized Cancer Vaccines
Personalized Cancer Vaccines
Anna Azvolinsky | Apr 2, 2015
A dendritic cell vaccine targeting melanoma patients’ tumor-specific mutations can activate a broad range of cancer-fighting T cells. 
Stem Cell Divisions Help Explain Cancer Risk
Stem Cell Divisions Help Explain Cancer Risk
Anna Azvolinsky | Jan 1, 2015
An analysis of 31 tissues finds that random mutations acquired during stem cell divisions correlate with lifetime cancer risk.  
Mosaic Mutations
Mosaic Mutations
Kate Yandell | Jul 31, 2014
Some genetic abnormalities that appear to have sprung up independently in children are in fact present in a portion of their parents’ cells.
Mutation Patterns Underlie Cancers
Mutation Patterns Underlie Cancers
Kerry Grens | Aug 15, 2013
More than 20 genome-wide mutational “signatures” account for the vast majority of 30 common cancers.
New Type of DNA Discovered?
Sabrina Richards | Mar 8, 2012
Small circles of extrachromosomal DNA appear to be widespread in mammals, and may be byproducts of small deletions in the nuclear DNA of somatic cells.
Deconstructing the Mosaic Brain
Tom Curran | Aug 1, 2011
Sequencing the DNA of individual neurons is a way to dissect the genes underlying major neurological and psychological disorders.